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Construction of relapse-related lncRNA-mediated ceRNA networks in Hodgkin lymphoma
Archives of Medical Science ( IF 3.0 ) Pub Date : 2020-09-09 , DOI: 10.5114/aoms.2020.98839 Yuexiong Liang 1 , Haifeng Zhu 1 , Jing Chen 1 , Wei Lin 1 , Bing Li 1 , Yusheng Guo 2
Archives of Medical Science ( IF 3.0 ) Pub Date : 2020-09-09 , DOI: 10.5114/aoms.2020.98839 Yuexiong Liang 1 , Haifeng Zhu 1 , Jing Chen 1 , Wei Lin 1 , Bing Li 1 , Yusheng Guo 2
Affiliation
Introduction
Hodgkin lymphoma (HL) is a type of lymphoma common throughout the western countries. However, the detailed mechanisms and special biomarkers of HL remain to be further investigated. Emerging studies have shown that long non-coding RNAs play a key role in human cancers.
Material and methods
In the present work, we constructed relapse-related lncRNA-mediated ceRNA networks in HL. Additionally, we constructed co-expression networks for these relapse-related lncRNAs. We also constructed a relapse-related lncRNA-miRNA-mRNA network to study the potential mechanism of these lncRNAs. Furthermore, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to explore functions of DEGs in Hodgkin lymphoma.
Results
A total of 18 lncRNAs were found to be dysregulated between early relapse and late relapse HL. Six lncRNAs (PCBP1-AS1, HCG18, GAS5, PSMD6-AS2, PRKCQ-AS1, SNHG6), 116 mRNAs and 121 miRNAs were included in the ceRNA network. Bioinformatics analyses revealed that these lncRNAs were significantly involved in regulating immune system processes, responses to chemical stimuli and responses to stress. Among them, HCG18 and PCBP1-AS1 were identified as key lncRNAs in HL relapse.
Conclusions
Our results for the first time constructed the key relapse-related lncRNA-mediated ceRNA networks in Hodgkin lymphoma progression. We trust that this work will provide a new therapeutic and prognostic target for HL.
中文翻译：
霍奇金淋巴瘤复发相关lncRNA介导的ceRNA网络的构建
简介
霍奇金淋巴瘤 (HL) 是一种常见于西方国家的淋巴瘤。然而，HL的详细机制和特殊生物标志物仍有待进一步研究。新兴研究表明，长链非编码 RNA 在人类癌症中起着关键作用。
材料和方法
在目前的工作中，我们在 HL 中构建了与复发相关的 lncRNA 介导的 ceRNA 网络。此外，我们为这些复发相关的 lncRNA 构建了共表达网络。我们还构建了一个与复发相关的 lncRNA-miRNA-mRNA 网络来研究这些 lncRNA 的潜在机制。此外，还进行了基因本体论 (GO) 和京都基因和基因组百科全书 (KEGG) 通路分析，以探索 DEG 在霍奇金淋巴瘤中的功能。
结果
共发现 18 个 lncRNA 在早期复发和晚期复发 HL 之间失调。ceRNA网络中包含6个lncRNA（PCBP1-AS1、HCG18、GAS5、PSMD6-AS2、PRKCQ-AS1、SNHG6）、116个mRNA和121个miRNA。生物信息学分析表明，这些 lncRNA 显着参与调节免疫系统过程、对化学刺激的反应和对压力的反应。其中，HCG18和PCBP1-AS1被确定为HL复发的关键lncRNA。
结论
我们的结果首次构建了霍奇金淋巴瘤进展中与复发相关的关键 lncRNA 介导的 ceRNA 网络。我们相信这项工作将为 HL 提供一个新的治疗和预后目标。
更新日期：2020-11-03
Hodgkin lymphoma (HL) is a type of lymphoma common throughout the western countries. However, the detailed mechanisms and special biomarkers of HL remain to be further investigated. Emerging studies have shown that long non-coding RNAs play a key role in human cancers.
Material and methods
In the present work, we constructed relapse-related lncRNA-mediated ceRNA networks in HL. Additionally, we constructed co-expression networks for these relapse-related lncRNAs. We also constructed a relapse-related lncRNA-miRNA-mRNA network to study the potential mechanism of these lncRNAs. Furthermore, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to explore functions of DEGs in Hodgkin lymphoma.
Results
A total of 18 lncRNAs were found to be dysregulated between early relapse and late relapse HL. Six lncRNAs (PCBP1-AS1, HCG18, GAS5, PSMD6-AS2, PRKCQ-AS1, SNHG6), 116 mRNAs and 121 miRNAs were included in the ceRNA network. Bioinformatics analyses revealed that these lncRNAs were significantly involved in regulating immune system processes, responses to chemical stimuli and responses to stress. Among them, HCG18 and PCBP1-AS1 were identified as key lncRNAs in HL relapse.
Conclusions
Our results for the first time constructed the key relapse-related lncRNA-mediated ceRNA networks in Hodgkin lymphoma progression. We trust that this work will provide a new therapeutic and prognostic target for HL.
中文翻译：
霍奇金淋巴瘤复发相关lncRNA介导的ceRNA网络的构建
简介
霍奇金淋巴瘤 (HL) 是一种常见于西方国家的淋巴瘤。然而，HL的详细机制和特殊生物标志物仍有待进一步研究。新兴研究表明，长链非编码 RNA 在人类癌症中起着关键作用。
材料和方法
在目前的工作中，我们在 HL 中构建了与复发相关的 lncRNA 介导的 ceRNA 网络。此外，我们为这些复发相关的 lncRNA 构建了共表达网络。我们还构建了一个与复发相关的 lncRNA-miRNA-mRNA 网络来研究这些 lncRNA 的潜在机制。此外，还进行了基因本体论 (GO) 和京都基因和基因组百科全书 (KEGG) 通路分析，以探索 DEG 在霍奇金淋巴瘤中的功能。
结果
共发现 18 个 lncRNA 在早期复发和晚期复发 HL 之间失调。ceRNA网络中包含6个lncRNA（PCBP1-AS1、HCG18、GAS5、PSMD6-AS2、PRKCQ-AS1、SNHG6）、116个mRNA和121个miRNA。生物信息学分析表明，这些 lncRNA 显着参与调节免疫系统过程、对化学刺激的反应和对压力的反应。其中，HCG18和PCBP1-AS1被确定为HL复发的关键lncRNA。
结论
我们的结果首次构建了霍奇金淋巴瘤进展中与复发相关的关键 lncRNA 介导的 ceRNA 网络。我们相信这项工作将为 HL 提供一个新的治疗和预后目标。
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