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Changes in circulating stem cells and endothelial progenitor cells over a 12-month period after implantation of a continuous-flow left ventricular assist device
Archives of Medical Science ( IF 3.0 ) Pub Date : 2020-11-02 , DOI: 10.5114/aoms.2020.100306 Peter Ivak 1, 2, 3 , Ivan Netuka 1, 3 , Ivana Kralova-Lesna 1, 4 , Peter Wohlfahrt 1 , Jan Pitha 1, 5
Archives of Medical Science ( IF 3.0 ) Pub Date : 2020-11-02 , DOI: 10.5114/aoms.2020.100306 Peter Ivak 1, 2, 3 , Ivan Netuka 1, 3 , Ivana Kralova-Lesna 1, 4 , Peter Wohlfahrt 1 , Jan Pitha 1, 5
Affiliation
Introduction
Changes in circulating CD34+CD45low stem cells (SC) and CD34+CD45low+KDR+ endothelial progenitor cells (EPC) may reflect pathological endothelial activation. Non-pulsatile/continuous-flow left ventricular assist devices (CF-LVAD) can enhance this process. The aim of this study was to analyse the impact of 12-month CF-LVAD treatment on SC and EPC.
Methods
We analysed changes in SC and EPC from the pre-implantation period up until 12 months after implantation over 3-month intervals in 14 patients. Data from 12 patients with heart failure (HF) and from 13 healthy volunteers were used as controls.
Results
Baseline EPC were significantly higher in CF-LVAD and HF patients than in healthy controls, substantially decreasing 3 months after CF-LVAD implantation and then returning to high baseline values at 12 months.
Conclusions
Changes in circulating SC and EPC may reflect pathological endothelial activation after CF-LVAD implantation.
中文翻译：
植入连续流动左心室辅助装置后 12 个月内循环干细胞和内皮祖细胞的变化
引言
循环 CD34+CD45low 干细胞 (SC) 和 CD34+CD45low+KDR+ 内皮祖细胞 (EPC) 的变化可能反映病理性内皮活化。非脉动/连续流动左心室辅助装置 (CF-LVAD) 可以增强这一过程。本研究的目的是分析 12 个月 CF-LVAD 治疗对 SC 和 EPC 的影响。
方法
我们分析了 14 名患者从植入前到植入后 12 个月的 SC 和 EPC 变化，间隔 3 个月。来自 12 名心力衰竭 (HF) 患者和 13 名健康志愿者的数据用作对照。
结果
CF-LVAD 和 HF 患者的基线 EPC 显着高于健康对照组，在 CF-LVAD 植入后 3 个月显着下降，然后在 12 个月时恢复到高基线值。
结论
循环 SC 和 EPC 的变化可能反映了 CF-LVAD 植入后的病理性内皮活化。
更新日期：2020-11-03
Changes in circulating CD34+CD45low stem cells (SC) and CD34+CD45low+KDR+ endothelial progenitor cells (EPC) may reflect pathological endothelial activation. Non-pulsatile/continuous-flow left ventricular assist devices (CF-LVAD) can enhance this process. The aim of this study was to analyse the impact of 12-month CF-LVAD treatment on SC and EPC.
Methods
We analysed changes in SC and EPC from the pre-implantation period up until 12 months after implantation over 3-month intervals in 14 patients. Data from 12 patients with heart failure (HF) and from 13 healthy volunteers were used as controls.
Results
Baseline EPC were significantly higher in CF-LVAD and HF patients than in healthy controls, substantially decreasing 3 months after CF-LVAD implantation and then returning to high baseline values at 12 months.
Conclusions
Changes in circulating SC and EPC may reflect pathological endothelial activation after CF-LVAD implantation.
中文翻译：
植入连续流动左心室辅助装置后 12 个月内循环干细胞和内皮祖细胞的变化
引言
循环 CD34+CD45low 干细胞 (SC) 和 CD34+CD45low+KDR+ 内皮祖细胞 (EPC) 的变化可能反映病理性内皮活化。非脉动/连续流动左心室辅助装置 (CF-LVAD) 可以增强这一过程。本研究的目的是分析 12 个月 CF-LVAD 治疗对 SC 和 EPC 的影响。
方法
我们分析了 14 名患者从植入前到植入后 12 个月的 SC 和 EPC 变化，间隔 3 个月。来自 12 名心力衰竭 (HF) 患者和 13 名健康志愿者的数据用作对照。
结果
CF-LVAD 和 HF 患者的基线 EPC 显着高于健康对照组，在 CF-LVAD 植入后 3 个月显着下降，然后在 12 个月时恢复到高基线值。
结论
循环 SC 和 EPC 的变化可能反映了 CF-LVAD 植入后的病理性内皮活化。
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