Abstract

This work aimed at the encapsulation of zinc phthalocyanine (ZnPc) in poly(thioether-ester) (PTEe) nanoparticles via thiol-ene miniemulsion polymerization using a biobased diene monomer and two different thiols as comonomers. ZnPc – PTEe nanoparticles presented an average diameter between 120 and 160 nm and high encapsulation efficiency for both thiols. The release profile of ZnPc from PTEe nanoparticles presented an initial burst effect followed by a slow release rate. Studies of cytotoxicity showed that the PTEe nanoparticles protected erythrocytes against ZnPc decreasing hemolytic damages. Moreover, a low concentration of ZnPc loaded in PTEe nanoparticles ensured the phototoxic effect on the MDA-MB231.

摘要

这项工作旨在使用生物基二烯单体和两种不同的硫醇作为共聚单体，通过硫醇-烯细乳液聚合将锌酞菁 (ZnPc) 封装在聚（硫醚酯） (PTEe) 纳米颗粒中。ZnPc – PTEe 纳米粒子的平均直径介于 120 和 160 nm 之间，并且对两种硫醇都有很高的封装效率。PTEe 纳米颗粒中 ZnPc 的释放曲线呈现出最初的爆发效应，然后是缓慢的释放速率。细胞毒性研究表明，PTEe 纳米颗粒可保护红细胞免受 ZnPc 的损害，从而减少溶血性损伤。此外，负载在 PTEe 纳米颗粒中的低浓度 ZnPc 确保了对 MDA-MB231 的光毒性作用。