ABSTRACT

The innate immune system relies on a germ-line-encoded repertoire of pattern recognition receptors (PRRs), activated by deeply conserved pathogen signatures, such as bacterial cell wall components or foreign nucleic acids. To enable effective defence against invading pathogens and prevent from deleterious inflammation, PRR-driven immune responses are tightly controlled by a dense network of nuclear and cytoplasmic regulators. Long non-coding RNAs (lncRNAs) are increasingly recognized as important components of these regulatory circuitries, providing positive and negative control of PRR-induced innate immune responses. The present review provides an overview of the presently known roles of lncRNAs in human and murine innate antiviral and antibacterial immunity. The emerging roles in host defence and inflammation suggest that further mechanistic insights into the cellular functions of lncRNAs will decisively advance our molecular understanding of immune-associated diseases and open new avenues for therapeutic intervention.

摘要

先天免疫系统依赖于模式识别受体 (PRR) 的种系编码库，由高度保守的病原体特征激活，例如细菌细胞壁成分或外源核酸。为了能够有效防御入侵的病原体并防止有害炎症，PRR 驱动的免疫反应受到密集的核和细胞质调节器网络的严格控制。长链非编码 RNA (lncRNAs) 越来越被认为是这些调节回路的重要组成部分，为 PRR 诱导的先天免疫反应提供阳性和阴性控制。本综述概述了目前已知的 lncRNA 在人和鼠先天性抗病毒和抗菌免疫中的作用。