Abstract

Gut barrier controls the food tolerance as well as host defense against potential hazards. The gut epithelium has been extensively studied for its importance in the structure and function of gut barrier. Recently, a new concept of barrier, named gut vascular barrier (GVB) has been discovered in both mice and human. Subsequent studies identified the morphological characteristics of GVB, the involved signaling events and its association with clinical diseases. In current study, we will summarize recent breakthroughs of GVB, with particular attentions to the molecular basis of GVB dysfunction. We will perform bioinformatics analysis to compare the transcriptional profiles of endothelium between blood and lymphatic vessels, healthy and inflammatory bowel diseases (IBD), healthy and colorectal cancer in the absence or presence of liver metastasis. We will further discuss the significance of impaired GVB in associated diseases, including vascular diseases, IBD and cancer metastasis. Our study will provide insights into the new concept of gut barrier, and promote the development of new strategies toward the vascular endothelium in the management of various diseases.

摘要

肠道屏障控制食物耐受性以及宿主对潜在危害的防御。肠道上皮因其在肠道屏障结构和功能中的重要性而被广泛研究。最近，在小鼠和人类中都发现了一种新的屏障概念，称为肠道血管屏障 (GVB)。随后的研究确定了 GVB 的形态特征、所涉及的信号事件及其与临床疾病的关联。在当前的研究中，我们将总结 GVB 的最新突破，特别关注 GVB 功能障碍的分子基础。我们将进行生物信息学分析，以比较血管和淋巴管、健康和炎症性肠病 (IBD)、健康和结直肠癌之间的内皮转录谱，无论是否存在肝转移。我们将进一步讨论受损 GVB 在相关疾病中的重要性，包括血管疾病、IBD 和癌症转移。我们的研究将为肠道屏障的新概念提供见解，并促进血管内皮管理各种疾病的新策略的发展。