ABSTRACT

Introduction: Sepsis, a dysregulated host response to infection, is a major cause of morbidity and mortality worldwide. Early identification and evidence-based treatment of sepsis are associated with improved outcomes.

Areas covered: This narrative review was undertaken following a PubMed search for English language reports published before July 2020 using the terms ‘sepsis,’ ‘septic shock,’ ‘fluids,’ ‘fluid therapy,’ ‘albumin,’ ‘corticosteroids,’ ‘vasopressor.’ Emerging management strategies were identified following a search of the ClinicalTrails.gov database using the term ‘sepsis.’ Additional reports were identified by examining the reference lists of selected articles and based on personnel knowledge of the field of sepsis.

Expert opinion: The core treatment of sepsis relies on source control, early antibiotics, and organ support. The main emerging strategies focus on immunomodulation, artificial intelligence, and on multi-omics approaches for a personalized therapy.

摘要

简介：败血症是宿主对感染的失调反应，是全世界发病率和死亡率的主要原因。脓毒症的早期识别和循证治疗与改善结果相关。

涵盖的领域：本叙述性审查是在 PubMed 搜索 2020 年 7 月之前发表的英语报告后进行的，使用术语“脓毒症”、“感染性休克”、“液体”、“液体疗法”、“白蛋白”、“皮质类固醇”、“血管加压药。在使用术语“脓毒症”搜索 ClinicalTrails.gov 数据库后，确定了新兴的管理策略。通过检查选定文章的参考文献列表并基于脓毒症领域的人员知识，确定了其他报告。

专家意见：败血症的核心治疗依赖于源头控制、早期抗生素和器官支持。主要的新兴策略集中在免疫调节、人工智能和个性化治疗的多组学方法上。