Abstract

The drug rapamycin is a potent inhibitor of the mTOR complex, acting directly in the signaling cascade of this protein complex; interrupting cell proliferation, in addition to being an extremely efficient immunosuppressant. Currently this drug is being used in several types of cancer. Rapamycin has been a target of great interest within nanomedicine involving nanostructured systems for drug delivery aiming to increase the bioactivity and bioavailability of this drug. In addition, there is a constant search for analytical methods to identify and quantify this drug. Numerous high-performance liquid chromatography analytical techniques, mass spectrometry and immunoassay techniques have been employed efficiently in an attempt to develop increasingly sensitive analytical methods. Thus, this review sought to bring together current and relevant scientific works involving rapamycin and; besides analytical methods more used for quantification of this molecule.

摘要

药物雷帕霉素是 mTOR 复合物的强效抑制剂，直接作用于这种蛋白质复合物的信号级联反应；除了是一种非常有效的免疫抑制剂外，还可以阻断细胞增殖。目前，这种药物被用于几种类型的癌症。雷帕霉素一直是纳米医学中非常感兴趣的目标，涉及用于药物递送的纳米结构系统，旨在提高该药物的生物活性和生物利用度。此外，一直在寻找分析方法来识别和量化这种药物。许多高效液相色谱分析技术、质谱和免疫测定技术已被有效地采用，以尝试开发越来越灵敏的分析方法。因此，该审查旨在汇集涉及雷帕霉素的当前和相关科学工作；除了更多用于定量这种分子的分析方法。