The first total synthesis of the allene-containing cyclic tetrapeptide pseudoxylallemycin C is reported. The Tyr(t-Bu)-protected linear peptide was prepared on-resin and cyclized in solution phase to yield the protected cyclic precursor. Upon deprotection of Tyr(t-Bu), the desired phenolic cyclic tetrapeptide was separated by RP-HPLC from its epimer that also formed during the macrocyclisation step. Subsequent alkylation with 4-bromobuta-1,2-diene yielded pseudoxylallemycin C.

中文翻译：

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含异戊烯的环四肽伪氧化乐乐霉素C的全合成

报道了含丙二烯的环状四肽假木糖精C的第一个全合成。Tyr（t-Bu）保护的线性肽是在树脂上制备的，并在溶液相中环化以生成受保护的环状前体。Tyr（t-Bu）脱保护后，所需的酚类环状四肽通过RP-HPLC从其差向异构体中分离出来，该差向异构体也在大环化步骤中形成。随后用4-溴丁烯-1,2-二烯进行烷基化反应得到假木糖精C.