The prioritized net benefit (Δ) is a measure of the benefit‐risk balance in clinical trials, based on generalized pairwise comparisons (GPC) using several prioritized outcomes. Its estimation requires the classification as Wins or Losses of all possible pairs of patients, one from the experimental treatment (E) group and one from the control treatment (C) group. In this simulation study, we assessed the impact of the correlation between prioritized outcomes on Δ, its estimate, bias, size, and power.

中文翻译：

---

使用广义成对比较在存在相关优先结果的情况下的净收益：模拟研究

优先级净收益（Δ）是衡量临床试验中受益风险平衡的一种指标，它基于使用多个优先结果的广义成对比较（GPC）。其估计需要将所有可能的患者对分类为成败，一组来自实验治疗（E）组，另一组来自对照治疗（C）组。在此模拟研究中，我们评估了优先结果与Δ之间的相关性，其估计值，偏差，大小和功效的影响。