Modeling neurodevelopment in a dish with pluripotent stem cells,Development, Growth & Differentiation

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Modeling neurodevelopment in a dish with pluripotent stem cells
Development, Growth & Differentiation ( IF 1.7 ) Pub Date : 2020-11-03 , DOI: 10.1111/dgd.12699
Kent Imaizumi ₁ , Hideyuki Okano ₁

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Pluripotent stem cells (PSCs) can differentiate into all cell types in the body, and their differentiation procedures recapitulate the developmental processes of embryogenesis. Focusing on neurodevelopment, we describe here the application of knowledge gained from embryology to the neural induction of PSCs. Furthermore, PSC‐based neural modeling provides novel insights into neurodevelopmental processes. In particular, human PSC cultures are a powerful tool for the study of human‐specific neurodevelopmental processes and could even enable the elucidation of the mechanisms of human brain evolution. We also discuss challenges and potential future directions in further improving PSC‐based neural modeling.

中文翻译：

用多能干细胞在培养皿中模拟神经发育

多能干细胞（PSC）可以分化为体内所有细胞类型，其分化过程概括了胚胎发生的发育过程。我们重点关注神经发育，在此描述了从胚胎学获得的知识在 PSC 神经诱导中的应用。此外，基于 PSC 的神经模型为神经发育过程提供了新的见解。特别是，人类 PSC 培养物是研究人类特定神经发育过程的有力工具，甚至可以阐明人类大脑进化机制。我们还讨论了进一步改进基于 PSC 的神经模型的挑战和潜在的未来方向。

更新日期：2020-11-03

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