当前位置：
X-MOL 学术
›
Drug Test. Anal.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
New qualitative analysis strategy for illicit drugs using Raman spectroscopy and characteristic peaks method
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-11-03 , DOI: 10.1002/dta.2963 Cui-Mei Liu 1 , Hong-Yuan He 2 , Lin Xu 2 , Zhen-Dong Hua 1
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-11-03 , DOI: 10.1002/dta.2963 Cui-Mei Liu 1 , Hong-Yuan He 2 , Lin Xu 2 , Zhen-Dong Hua 1
Affiliation
|
Performing fast qualitative identification of seized illegal drugs by Raman spectroscopy is challenging due to fluorescence interference as well as chemical complexity. Spectrometers with 785‐nm excitation, 1,064‐nm excitation, and sequentially shifted excitation (SSE) were compared for their effect on fluorescence reduction. The characteristic peaks method, which is independent of cutting agents, was tested as a new strategy to broaden the application of the Raman technique. The suitability of the characteristic peaks method was fully examined by analyzing a large amount of seized illegal drugs, including 72 methamphetamine hydrochloride (concentration range of 13.9%–99.4%), 68 ketamine hydrochloride (17.7%–99.8%), 176 heroin hydrochloride (5.2%–79.5%), 51 cocaine hydrochloride (21.1%–94.5%), and 33 cocaine base (30.9%–92.5%) samples. The results showed that seized methamphetamine, ketamine, and cocaine samples had no or little fluorescence. Hence, in regard to detection of these samples, the advantage of using 1,064‐nm excitation and SSE compared with 785‐nm excitation was quite limited. Regarding the heroin samples, a significant improvement of the “high” confident positive detected rate was evident for 1,064 nm excitation (60.8%) and SSE (61.4%), compared with 785‐nm excitation (13.1%). However, it was also seen that even if 1,064‐nm excitation and SSE were applied, the fluorescence of heroin samples was still unable to be fully overcome. By using the characteristic peaks method, low LOD results of 5%–20% were acquired for 40 types of drug mixtures, and lower LODs were obtained for the 60% of the drug mixtures compared with library searching method. Raman spectroscopy in conjunction with the characteristic peaks method was shown to be fast, simple, accurate, and sensitive in the qualitative analysis of seized drug samples.
中文翻译：
使用拉曼光谱和特征峰法对非法药物进行新的定性分析策略
由于荧光干扰和化学复杂性，通过拉曼光谱对缉获的非法毒品进行快速定性鉴定具有挑战性。比较了具有 785 nm 激发、1,064 nm 激发和顺序偏移激发 (SSE) 的光谱仪对荧光减少的影响。独立于切割剂的特征峰方法被测试为扩大拉曼技术应用的新策略。通过对大量缉获毒品的分析，包括72种盐酸甲基苯丙胺（浓度范围13.9%~99.4%）、68种盐酸氯胺酮（17.7%~99.8%）、176种盐酸海洛因（ 5.2%–79.5%)、51 个可卡因盐酸盐 (21.1%–94.5%) 和 33 个可卡因碱 (30.9%–92.5%) 样品。结果表明，缉获的甲基苯丙胺、氯胺酮和可卡因样品没有或几乎没有荧光。因此，对于这些样品的检测，与 785 nm 激发相比，使用 1,064 nm 激发和 SSE 的优势非常有限。关于海洛因样品，与 785 nm 激发 (13.1%) 相比，1,064 nm 激发 (60.8%) 和 SSE (61.4%) 的“高”置信阳性检测率明显提高。然而，也看到即使应用 1,064 nm 激发和 SSE，海洛因样品的荧光仍然无法完全克服。使用特征峰法对40种药物混合物获得了5%~20%的低LOD结果，与库搜索法相比，60%的药物混合物获得了更低的LOD。
更新日期：2020-11-03
中文翻译：
使用拉曼光谱和特征峰法对非法药物进行新的定性分析策略
由于荧光干扰和化学复杂性，通过拉曼光谱对缉获的非法毒品进行快速定性鉴定具有挑战性。比较了具有 785 nm 激发、1,064 nm 激发和顺序偏移激发 (SSE) 的光谱仪对荧光减少的影响。独立于切割剂的特征峰方法被测试为扩大拉曼技术应用的新策略。通过对大量缉获毒品的分析，包括72种盐酸甲基苯丙胺（浓度范围13.9%~99.4%）、68种盐酸氯胺酮（17.7%~99.8%）、176种盐酸海洛因（ 5.2%–79.5%)、51 个可卡因盐酸盐 (21.1%–94.5%) 和 33 个可卡因碱 (30.9%–92.5%) 样品。结果表明，缉获的甲基苯丙胺、氯胺酮和可卡因样品没有或几乎没有荧光。因此，对于这些样品的检测，与 785 nm 激发相比，使用 1,064 nm 激发和 SSE 的优势非常有限。关于海洛因样品，与 785 nm 激发 (13.1%) 相比，1,064 nm 激发 (60.8%) 和 SSE (61.4%) 的“高”置信阳性检测率明显提高。然而，也看到即使应用 1,064 nm 激发和 SSE，海洛因样品的荧光仍然无法完全克服。使用特征峰法对40种药物混合物获得了5%~20%的低LOD结果，与库搜索法相比，60%的药物混合物获得了更低的LOD。
京公网安备 11010802027423号