Postural orthostatic tachycardia syndrome (POTS) is a disorder of orthostatic intolerance associated with many GI manifestations that can be broadly classified into two different categories: those present all the time (non‐positional) and those that occur with orthostatic position change. There are also many conditions that can co‐exist with POTS such as mast cell activation syndrome and the hypermobile form of Ehlers‐Danlos syndrome (hEDS) that are also oftentimes associated with GI symptoms. In the current issue of Neurogastroenterology and Motility, Tai et al. explored the relationship between functional GI disorders among hEDS patients with and without concomitant POTS and showed that the hEDS‐POTS cohort was more likely to have more than one GI organ involved compared to the cohort with hEDS alone, and certain GI symptoms were also more common in the hEDS‐POTS cohort. In this review article, we will briefly review the literature surrounding putative mechanisms responsible for GI symptoms in POTS with an emphasis on the contributory role of concomitant hEDS and then discuss management strategies for GI symptoms in POTS.

中文翻译：

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体位性心动过速综合征胃肠道症状的机制和处理

体位性直立性心动过速综合征 (POTS) 是一种直立性不耐受疾病，与许多胃肠道表现相关，可大致分为两类：一直存在的（非体位性）和体位改变时发生的体位性心动过速。还有许多情况可以与 POTS 共存，例如肥大细胞激活综合征和 Ehlers-Danlos 综合征 (hEDS) 的过度活动形式，这些情况也经常与 GI 症状相关。在本期《神经胃肠病学和动力》中，泰等人。探讨了伴有和不伴有 POTS 的 hEDS 患者的功能性胃肠道疾病之间的关系，并表明与单独 hEDS 的队列相比，hEDS-POTS 队列更有可能涉及一个以上的 GI 器官，并且某些胃肠道症状也更常见在 hEDS-POTS 队列中。在这篇综述文章中，我们将简要回顾有关 POTS 中胃肠道症状的假定机制的文献，重点是伴随 hEDS 的促成作用，然后讨论 POTS 中胃肠道症状的管理策略。