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Validation of a new hand function outcome measure in individuals with Charcot‐Marie‐Tooth disease
Journal of the Peripheral Nervous System ( IF 3.9 ) Pub Date : 2020-11-02 , DOI: 10.1111/jns.12421
Valeria Prada 1 , Giulia Robbiano 1 , Giulia Mennella 1 , Mehrnaz Hamedani 1 , Emilia Bellone 1, 2 , Marina Grandis 1, 2 , Angelo Schenone 1, 2 , Riccardo Zuccarino 3, 4
Affiliation  

The symptomatology of Charcot‐Marie‐Tooth (CMT) disease mainly involves the feet and the hands. To date, there is no consensus on how to evaluate hand function in CMT. The aim of this study is to correlate the data of the engineered glove Hand Test System (HTS) with specific tests and the CMT examination score (CMTES). We analyzed 45 patients with the diagnosis of CMT using HTS, which measures the hand dexterity by specific sequences performed at maximum velocity. We completed the evaluation with the CMTES, tripod pinch and hand grip strength tested by a dynamometer, thumb opposition test (TOT), and Sollerman Hand function test (SHFT), and we conducted a test‐retest with 20 normal subjects. Finger tapping (FT) and index‐medium‐ring‐little (IMRL) sequence showed a significant correlation with CMTES (FT: dominant hand (DH): P = .036; non‐dominant hand (NDH): P = .033; IMRL: DH: P = .009; NDH: P = .046). TOT correlated with CMTES significantly in both hands (P < .0001). tripod pinch showed a statistically significant correlation with CMTES (DH: P = .002; NDH: P = .005). Correlation between the hand grip and CMTES was significant only in DH (DH: P = .002). SHFT had a significant correlation with the CMTES (DH: P = .002). Test‐retest showed a good reliability. HTS parameters correlate with CMTES confirming that this tool is sensitive to the hand deficits. In conclusion, we can state that HTS is a good, simple to use, and objective instrument to evaluate the hand function of CMT patients, but more studies on responsiveness and sensitivity are needed.

中文翻译:

在 Charcot-Marie-Tooth 病患者中验证新的手功能结果测量

Charcot-Marie-Tooth (CMT) 病的症状主要涉及脚和手。迄今为止,关于如何在 CMT 中评估手部功能还没有达成共识。本研究的目的是将工程手套手部测试系统 (HTS) 的数据与特定测试和 CMT 考试分数 (CMTES) 相关联。我们使用 HTS 分析了 45 名诊断为 CMT 的患者,HTS 通过以最大速度执行的特定序列测量手的灵活性。我们通过测力计、拇指对立测试(TOT)和索勒曼手部功能测试(SHFT)测试了CMTES、三脚架捏合力和握力测试,并对20名正常受试者进行了重新测试。手指敲击 (FT) 和索引-中-环-小 (IMRL) 序列与 CMTES (FT: 优势手 (DH):P = .036;非惯用手(NDH):P = .033;IMRL:DH:P = .009 ;NDH:P = .046)。TOT 与双手的 CMTES 显着相关 ( P  < .0001)。三脚架夹点与 CMTES 具有统计学上的显着相关性(DH:P = .002;NDH:P = .005)。手柄和 CMTES 之间的相关性仅在 DH 中显着(DH:P = .002)。SHFT 与 CMTES 显着相关(DH:P= .002)。重测具有良好的信度。HTS 参数与 CMTES 相关,证实该工具对手部缺陷敏感。总之,我们可以说 HTS 是一种很好的、​​易于使用且客观的评估 CMT 患者手部功能的工具,但需要对反应性和敏感性进行更多的研究。
更新日期:2020-12-07
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