Aeromonas veronii is an important zoonotic and aquatic agent. More and more cases have shown that it has caused huge economic losses in the aquaculture industry in addition to threatening human health. But the reasons for the increasing virulence of A. veronii are still unclear. In order to further understand the reasons for the increased virulence of A. veronii, we conducted a comparative analysis of the genomes of A. veronii with different virulence. The analysis revealed that there are multiple virulence factors, such as those related to fimbriae, flagella, toxins, iron ion uptake systems and type II, type III and type VI secretion systems in the virulent strain TH0426 genome. And comparative analysis showed that there were two complete type III secretion systems (API1 and API2), of which the API2 and iron ion transport system were unique to the TH0426 strain. In addition, TH0426 strain also has unique functional gene clusters, which may play important roles in terms of resisting infection, adapting to different environments and genetic evolution. These particular virulence factors and gene clusters may be the important reasons for the increased virulence. These insights will provide a reference for the study of the pathogenesis of A. veronii.

中文翻译：

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不同毒力菌株的比较基因组分析揭示了维罗纳气单胞菌毒力增加的原因

Veronii气单胞菌是一种重要的人畜共患和水生媒介。越来越多的案例表明，除威胁人类健康外，它还给水产养殖业造成了巨大的经济损失。但是，仍然没有引起维罗纳弧菌毒性增加的原因。为了进一步了解拟南芥毒力增加的原因，我们对拟南芥的基因组进行了比较分析。具有不同的毒力。分析显示，在毒株TH0426基因组中存在多种毒力因子，例如与菌毛，鞭毛，毒素，铁离子摄取系统和II型，III型和VI型分泌系统有关的毒力因子。比较分析表明，有两个完整的III型分泌系统（API1和API2），其中API2和铁离子转运系统是TH0426菌株所独有的。此外，TH0426菌株还具有独特的功能基因簇，在抵抗感染，适应不同环境和遗传进化方面可能发挥重要作用。这些特定的毒力因子和基因簇可能是毒力增加的重要原因。这些见解将为研究肝癌的发病机理提供参考。A.veronii。