Alkynylation‐Desilylation‐Alkynylation‐Cycloisomerization (ADAC) Three‐Component Synthesis of 2,2′‐Biindolyls – Concise Synthesis of Tjipanazole I,ChemCatChem

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Alkynylation‐Desilylation‐Alkynylation‐Cycloisomerization (ADAC) Three‐Component Synthesis of 2,2′‐Biindolyls – Concise Synthesis of Tjipanazole I
ChemCatChem ( IF 3.8 ) Pub Date : 2020-11-02 , DOI: 10.1002/cctc.202001607
Sebastian Kustosz ₁ , Patrik Niesobski ₁ , Thomas J. J. Müller ₁

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A sequentially Pd/Cu‐catalyzed alkynylation‐desilylation‐alkynylation‐cycloisomerization (ADAC) process in the sense of a consecutive three‐component reaction using TIPS‐butadiyne as a four carbon building block gives a rapid and efficient access to 2,2′‐biindolyls in a one‐pot fashion. This facile entry to unsymmetrically substituted title compounds has been employed in a concise two‐step synthesis of the alga alkaloid tjipanazole I.

中文翻译：

炔基化-甲硅烷基化-炔基化-环异构化（ADAC）2,2'-联吲哚类的三组分合成–吉潘唑I的简便合成

在使用TIPS-丁二炔作为四碳构件的连续三组分反应的意义上，顺序进行Pd / Cu催化的炔基化-去甲硅烷基化-炔基化-环异构化（ADAC）过程可快速有效地获得2,2'-一锅法的二吲哚。这种不对称取代的标题化合物的简便输入方法已用于藻类生物碱吉潘唑I的简明两步合成中。

更新日期：2020-11-02

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