Abstract In recent years, the synthesis and introduction of Novel Psychoactive Substances (NPS) into the illicit market has reached alarming levels. More than 730 compounds have been identified by the European Monitoring Center for Drugs and Drug Addiction (EMCDDA). Among the newest NPS, synthetic opioids deserve special attention, in particular fentanyl and its analogues that in 2018 covered more than 70% of the world demand for opioids, with thousands of fatal events in USA. In this context it is of significant importance to have the right tools to identify the most recent NPS exploiting the synergy between different analytical techniques. Two synthetic opioids, belonging to the family of fentanyl derivatives were found in the same seizure occurred in Italy in 2019. IsobutyrylFentanyl (iBF) and 4-Fluoro-Furanylfentanyl (4F-FuF) were identified. A comprehensive elucidation of 4F-FuF by means of several analytical techniques, namely IR, Raman, GC-MS, LC-HRMS/MS and NMR, is provided in this work. In Italy, as a result of the present study, a formal notification of 4F-FuF to the national early warning system was sent and notification to EMCDDA ensued.

中文翻译：

---

缉获毒品中 4-氟-呋喃基芬太尼的多分析表征

摘要 近年来，新型精神活性物质 (NPS) 的合成和引入非法市场已达到令人震惊的程度。欧洲药物和药物成瘾监测中心 (EMCDDA) 已鉴定出 730 多种化合物。在最新的新型精神活性物质中，合成阿片类药物值得特别关注，尤其是芬太尼及其类似物，2018 年它们覆盖了全球 70% 以上的阿片类药物需求，在美国发生了数千起致命事件。在这种情况下，拥有正确的工具来利用不同分析技术之间的协同作用来识别最新的 NPS 是非常重要的。2019 年在意大利发生的同一次缉获中发现了两种属于芬太尼衍生物家族的合成阿片类药物。 确定了异丁酰芬太尼 (iBF) 和 4-氟-呋喃基芬太尼 (4F-FuF)。这项工作提供了通过几种分析技术，即 IR、拉曼、GC-MS、LC-HRMS/MS 和 NMR 对 4F-FuF 的全面阐明。在意大利，作为本研究的结果，向国家预警系统发出了 4F-FuF 的正式通知，随后向 EMCDDA 发出了通知。