Abstract Although many novel psychoactive drugs (NPSs) have emerged in the last decade, many of these drugs have not had their ultraviolet spectroscopic properties reported. Synthetic cathinones are one class of NPSs that such information is lacking. Properties such as maximum absorbance (λmax), molar absorptivity (e) and specific absorbance ( A 1 1 ) are valuable for characterizing drugs. Specific absorbance ( A 1 1 ) is defined as the maximum absorbance of a 1% solution over a 1-cm path length as measured by ultraviolet–visible spectroscopy (UV–Vis). The determination of a reliable A 1 1 is a useful alternative to quantitatively verify the concentration of analytical standard solutions. The UV spectral properties, λmax, e, and A 1 1 , of 20 synthetic cathinones were determined in methanol using three different UV–Vis spectrophotometers. UV spectrophotometry can be used to distinguish between positional isomers of synthetic cathinones when the differences are substituted on the benzene ring. It can also be used to detect substitution at the para position of the aromatic ring and the addition of a 3,4-methylenedioxy function group on the aromatic ring of synthetic cathinones. This information can potentially be helpful to forensic chemists in an identification scheme for the analysis of synthetic cathinones in seized drugs.

中文翻译：

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合成卡西酮的紫外线吸收特性

摘要 尽管在过去十年中出现了许多新型精神活性药物 (NPS)，但其中许多药物的紫外光谱特性尚未得到报道。合成卡西酮是一类缺乏此类信息的 NPS。诸如最大吸光度 (λmax)、摩尔吸光度 (e) 和比吸光度 (A 1 1 ) 等特性对于表征药物很有价值。比吸光度 (A 1 1 ) 定义为通过紫外-可见光谱 (UV-Vis) 测量的 1% 溶液在 1 厘米光程内的最大吸光度。确定可靠的 A 1 1 是定量验证分析标准溶液浓度的有用替代方法。使用三种不同的紫外-可见分光光度计在甲醇中测定了 20 种合成卡西酮的紫外光谱特性，λmax、e 和 A 1 1 。当差异在苯环上被取代时，紫外分光光度法可用于区分合成卡西酮的位置异构体。也可用于检测芳环对位取代和合成卡西酮芳环上3,4-亚甲二氧基官能团的加成。该信息可能有助于法医化学家在分析缉获药物中合成卡西酮的鉴定方案中有所帮助。