Abstract A new series of chalcone incorporated 2-quinoline-benzimidazole-1,2,4-thiadiazoles (9a-j) were designed, synthesized and examined for their anticancer activities against four different human cancer cell lines like MCF-7 (breast cancer), A549 (Lung cancer), Colo-205 (Colon cancer) and A2780 (Ovarian cancer) and compared with clinical drug candidate as etoposide. Among them, compound 9d showed potent anticancer activities against MCF-7, A549, Colo-205 and A2780 cell lines with IC50 values of 0.012±0.007 µM, 0.074±0.004 µM, 1.46±0.73 µM and 0.083±0.002 µM, respectively.

中文翻译：

---

1,2,4-噻二唑-苯并[d]咪唑-2-基)喹啉-2(1H)-酮查耳酮衍生物作为抗癌剂的合成与生物学评价

摘要 设计、合成了一系列新的查尔酮结合 2-喹啉-苯并咪唑-1,2,4-噻二唑 (9a-j) 并检测了它们对四种不同的人类癌细胞系如 MCF-7（乳腺癌）的抗癌活性、A549（肺癌）、Colo-205（结肠癌）和A2780（卵巢癌）并与作为依托泊苷的临床候选药物进行比较。其中，化合物9d对MCF-7、A549、Colo-205和A2780细胞系显示出有效的抗癌活性，IC50值分别为0.012±0.007 µM、0.074±0.004 µM、1.46±0.73 µM和0.082±0。