Herein, we describe a detailed preparation of the versatile pyrrole building block 3,4-diethylpyrrole-2-carboxylate (1), a key structural feature in various porphyrins, porphyrinoids, and other chromophores. 1 was prepared via a one-pot DBU catalyzed Henry reaction and acid catalyzed acetylation followed by an aqueous workup and telescoping through an adapted Magnus-Schöllkopf-Barton-Zard cyclization protocol from commercial starting materials. The three-step preparation utilized new chemistry, requires only one formal purification step, and affords 1 at 86% yield and >99% purity on a decagram scale.

中文翻译：

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方便的十克规模的乙基3,4-二乙基吡咯-2-羧酸乙酯的制备，这是吡咯基大环和生色团的通用前体

在这里，我们描述了多功能吡咯结构单元3,4-二乙基吡咯-2-羧酸盐（1）的详细制备，这是各种卟啉，卟啉类和其他生色团的关键结构特征。1经一锅DBU催化Henry反应和酸催化的乙酰化，随后水后处理和伸缩通过适于从商业起始材料马格纳斯Schöllkopf-巴顿ZARD环化方案制备。该三步制备方法采用了新的化学方法，仅需一个正式的纯化步骤即可提供，以十克计，收率为86％，纯度> 99％，为1。