Objective

To evaluate the cyclooxygenases (COX) inhibition, adverse effects and analgesic efficacy of dipyrone or meloxicam in cats undergoing elective ovariohysterectomy.

Study design

Prospective, blinded, randomized, clinical study.

Animals

A total of 30 healthy young cats.

Methods

The cats were randomly assigned to three postoperative groups: D25 (dipyrone 25 mg kg⁻¹ every 24 hours), D12.5 (dipyrone 12.5 mg kg⁻¹ every 12 hours) and M (meloxicam 0.1 mg kg⁻¹ every 24 hours). In the first 24 hours, the drugs were administered intravenously (IV), and then orally for 6 (dipyrone) or 3 days (meloxicam). Prostanoids thromboxane B₂ and prostaglandin E₂ concentrations served as indicators of COX activity and, with physiological variables and pain and sedation scores, were measured for 24 hours after first analgesic administration. Rescue analgesia (tramadol, 2 mg kg⁻¹ IV) was provided if Glasgow feline composite measure pain scale (CMPS-Feline) ≥5. Laboratory tests included symmetric dimethylarginine and adverse effects were evaluated regularly up to 7 and 10 days after surgery, respectively. Parametric and nonparametric data were analyzed with two-way anova and Kruskal-Wallis tests, respectively (p < 0.05).

Results

In the first half hour after analgesic administration, COX-1 activity was close to zero and remained significantly lower than before drug administration for 24 hours in all groups. The inhibition of COX-2 activity was significant for 30 minutes in all groups and up to 4 hours in group M. No alterations in laboratory tests or significant adverse effects were observed. Pain scores and need for rescue analgesia did not differ statistically among groups.

Conclusions

Dipyrone at both doses and meloxicam provided a nonselective inhibition of COX-1 and -2 activities and effective analgesia without causing significant adverse effects or laboratory tests alterations.

Clinical relevance

Dipyrone at both doses provides equally effective analgesia without causing adverse effects in cats undergoing ovariohysterectomy.

中文翻译：

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卵巢子宫切除术后猫对环氧化酶 1 和 2 的抑制作用和不同剂量的苯吡酮或美洛昔康的镇痛效果

客观的

评估苯吡酮或美洛昔康对接受选择性卵巢子宫切除术的猫的环氧合酶 (COX) 抑制、不良反应和镇痛效果。

学习规划

前瞻性、盲法、随机、临床研究。

动物

共30只健康幼猫。

方法

将猫随机分配到三个术后组：D25（每 24 小时服用苯吡酮25 mg kg ^-1）、D12.5（每 12 小时服用苯吡酮 12.5 mg kg ^-1）和 M（每 24 小时服用美洛昔康 0.1 mg kg ^-1） . 在最初的 24 小时内，药物通过静脉注射 (IV)，然后口服 6 天（苯吡酮）或 3 天（美洛昔康）。前列腺素血栓素 B ₂和前列腺素 E ₂浓度用作 COX 活性的指标，并在第一次镇痛药给药后 24 小时内测量生理变量和疼痛和镇静评分。救援镇痛（曲马多，2 mg kg ^-1IV) 如果格拉斯哥猫综合测量疼痛量表 (CMPS-Feline) ≥ 5，则提供。实验室测试包括对称二甲基精氨酸，并分别在手术后 7 天和 10 天定期评估不良反应。参数和非参数数据分别用双向方差分析和 Kruskal-Wallis 检验进行分析 ( p < 0.05)。

结果

各组镇痛给药后前半小时，COX-1活性接近于零，且24小时内均显着低于给药前。COX-2 活性的抑制在所有组中持续 30 分钟，在 M 组中长达 4 小时。没有观察到实验室测试的改变或显着的副作用。各组之间的疼痛评分和救援镇痛的需要没有统计学差异。

结论

两种剂量的苯吡酮和美洛昔康均提供对 COX-1 和 -2 活性的非选择性抑制和有效镇痛，而不会引起显着的不良反应或实验室测试改变。

临床相关性

两种剂量的苯吡酮都能提供同等有效的镇痛效果，而不会对接受卵巢子宫切除术的猫造成不良影响。