Nowadays, “all–in–one” nano–agent combing various phototherapeutic effects into one nano–system has been attracted more attention in cancer therapy. Herein, a new kind of photosensitizers (PSs) aggregate is designed and constructed. Tetra (4–carboxy phenyl) porphyrin (TCPP), acted as element, is used to form a sphere–like TCPP nanoparticles (TNP) by the self–assembly process. The obtained TNP not only shows good hydrophilia, but also possesses a high photothermal conversion efficiency (η = 31%) which the excessive energy from the excited singlet state (S_n) to the ground state (S₀) can be converted into heat. Moreover, TNP is served as photodynamic therapy (PDT) agent because of their components. The synergistic effect of PDT and photothermal therapy (PTT) gives TNP to superior antitumor performance under NIR laser irradiation. Meanwhile, TNP also exhibit an excellent biocompatible and safe for biomedical applications. This work provides novel insight for developing an outstanding phototherapeutic agent based on PSs aggregates to synergistically treat cancer.

如今，将多种光疗效果组合到一个纳米系统中的“多合一”纳米药物在癌症治疗中引起了更多关注。在此，设计并构建了一种新型的光敏剂（PSs）聚集体。四（4-羧基苯基）卟啉（TCPP）作为元素，通过自组装过程用于形成球形的TCPP纳米颗粒（TNP）。所获得的TNP不仅显示出良好的亲水性，而且还具有高的光热转化效率（η = 31％），其过量的能量从激发单重态（S _n）到基态（S _0））可以转化为热量。此外，由于其成分，TNP可用作光动力疗法（PDT）剂。PDT和光热疗法（PTT）的协同作用使TNP在近红外激光照射下具有出色的抗肿瘤性能。同时，TNP还具有出色的生物相容性，并且对生物医学应用安全。这项工作为开发基于PS聚集体的优异光疗剂以协同治疗癌症提供了新颖的见解。