The consensus model of glucose-stimulated insulin secretion (GSIS) holds that ATP generation by oxidative phosphorylation directly regulates K_ATP channel activity and thus insulin granule release, a concept inconsistent with bioenergetic principles. Here, Lewandowski et al. (2020) and Abulizi et al. (2020) report that regulation of GSIS is much more complex as different sources of ATP generation are essential to control this process, which can be targeted in vivo and additionally modulate hepatic glucose production. These findings establish an important new conceptual framework of GSIS and in vivo glucose homeostasis.

中文翻译：

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靶向丙酮酸激酶PEPs可增加胰岛素分泌并改善葡萄糖稳态

葡萄糖刺激的胰岛素分泌（GSIS）的共识模型认为，通过氧化磷酸化产生ATP可以直接调节K _ATP通道的活性，从而调节胰岛素颗粒的释放，这一概念与生物能原理不符。在这里，Lewandowski等。（2020年）和Abulizi等人。（2020）报道GSIS的调控要复杂得多，因为不同的ATP产生源对于控制该过程至关重要，而ATP可以在体内靶向并另外调节肝葡萄糖的产生。这些发现建立了GSIS和体内葡萄糖稳态的重要新概念框架。