Anticoagulant rodenticides (ARs) are commonly used to control rodent pests. However, worldwide, their use is associated with secondary and tertiary poisoning of nontarget species, especially predatory and scavenging birds. No medical device can rapidly test for AR exposure of avian wildlife. Prothrombin time (PT) is a useful biomarker for AR exposure, and multiple commercially available point-of-care (POC) devices measure PT of humans, and domestic and companion mammals. We evaluated the potential of one commercially available POC device, the Coag-Sense^® PT/INR Monitoring System, to rapidly detect AR exposure of living birds of prey. The Coag-Sense device delivered repeatable PT measurements on avian blood samples collected from four species of raptors trapped during migration (Intraclass Correlation Coefficient > 0.9; overall intra-sample variation CV: 5.7%). However, PT measurements reported by the Coag-Sense system from 81 ferruginous hawk (Buteo regalis) nestlings were not correlated to those measured by a one-stage laboratory avian PT assay (r = − 0.017, p = 0.88). Although precise, the lack of agreement in PT estimates from the Coag-Sense device and the laboratory assay indicates that this device is not suitable for detecting potential AR exposure of birds of prey. The lack of suitability may be related to the use of a mammalian reagent in the clotting reaction, suggesting that the device may perform better in testing mammalian wildlife

抗凝血灭鼠剂（ARs）通常用于控制啮齿动物害虫。但是，在世界范围内，它们的使用与非目标物种尤其是掠食性鸟类和清除性鸟类的第二次和第三次中毒有关。没有医疗设备可以快速测试禽类野生生物的AR暴露情况。凝血酶原时间（PT）是AR暴露的有用生物标志物，多种市售的即时护理（POC）设备可测量人类以及家养和陪伴哺乳动物的PT。我们评价一个商用POC设备，农委，观念的潜在^®PT / INR监控系统，可快速检测活体birds的AR暴露。Coag-Sense设备对从迁移过程中捕获的四种猛禽捕获的禽血样品进行了可重复的PT测量（类内相关系数> 0.9；样品内总体变异CV：5.7％）。但是，Coag-Sense系统报告的81头铁质鹰（Buteo regalis）雏鸟的PT测量值与一阶段实验室禽PT分析的测量值无关（r  = − 0.017，p = 0.88）。尽管很精确，但Coag-Sense设备与实验室测定的PT估算值不一致，表明该设备不适合检测猛禽的潜在AR暴露。缺乏适用性可能与在凝结反应中使用哺乳动物试剂有关，这表明该设备在测试哺乳动物野生动物方面可能表现更好