Brønsted acid-mediated reactions of ynamides,Chemical Society Reviews

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Brønsted acid-mediated reactions of ynamides
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2020-11-02 , DOI: 10.1039/d0cs00474j
Yang-Bo Chen _{1,

2,

3,

4,

5} , Peng-Cheng Qian _{5,

6,

7,

8,

9} , Long-Wu Ye _{1,

2,

3,

4,

5}

Affiliation

Over the past two decades, the development and application of ynamide chemistry have received more and more attention. Ynamides have proven to be versatile reagents for organic synthesis, and have been widely applied to the rapid assembly of a diverse range of structurally complex N-containing molecules, especially the valuable N-heterocycles. In comparison with the well-established transition metal-catalyzed reactions of ynamides, metal-free ynamide transformations have relatively seldom been exploited. Recently, Brønsted acid-mediated reactions of ynamides represent significant advances in ynamide chemistry. This review summarizes the latest trends and developments of Brønsted acid-mediated reactions of ynamides, including cycloaddition, cyclization, intramolecular alkoxylation-initiated rearrangement, oxygen atom transfer reactions and hydro-heteroatom addition reactions.

中文翻译：

布朗斯台德酸介导的酰胺反应

在过去的二十年中，乙酰胺化学的发展和应用受到了越来越多的关注。酰胺已被证明是有机合成的通用试剂，并已广泛应用于快速组装各种结构复杂的含N分子，尤其是有价值的N杂环。与公认的过渡金属催化的酰胺反应相比，相对很少开发无金属的酰胺转化。近来，布朗斯台德酸介导的酰胺的反应代表了酰胺化学的重大进展。这篇综述总结了布朗斯台德酸介导的酰胺反应的最新趋势和发展，包括环加成，环化，分子内烷氧基化引发的重排，

更新日期：2020-11-03

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