Active targeting of gold nanoparticles as cancer therapeutics,Chemical Society Reviews

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Active targeting of gold nanoparticles as cancer therapeutics
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2020-10-22 , DOI: 10.1039/d0cs01121e
Zoë Rachael Goddard _{1,

2,

3,

4,

5} , María J. Marín _{2,

3,

4,

5,

6} , David A. Russell _{2,

3,

4,

5,

6} , Mark Searcey _{1,

2,

3,

4,

5}

Affiliation

Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, with antibodies, proteins, peptides, aptamers, carbohydrates and small molecules all exploited. Here, we review the recent advances in targeted-AuNPs for the treatment of cancer, with a particular focus on these classes of targeting ligands. We highlight the benefits and potential drawbacks of each ligand class and propose directions in which the field could grow.

中文翻译：

主动靶向金纳米颗粒作为癌症治疗剂

金纳米颗粒（AuNPs）的独特性能及其生物相容性，最小毒性，多价和尺寸可调性使其成为令人兴奋的药物载体，因此受到越来越多的关注。具有靶向部分的AuNPs的功能性使其可以选择性地递送至癌症，而抗体，蛋白质，肽，适体，碳水化合物和小分子均被利用。在这里，我们回顾了靶向AuNPs在治疗癌症方面的最新进展，特别关注这些类型的靶向配体。我们重点介绍了每种配体的优缺点，并提出了该领域可以发展的方向。

更新日期：2020-11-03

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