In drug delivery an oral way is most perfect way for administration of active pharmaceutical ingredient (API) because of ease of management lead to high level of patient compliance. More than 50% of APIs are facing the major assignment with the design of orally administered dosage form that lies with their poor aqueous solubility and poor oral bioavailability mainly biopharmaceutical classification system (BCS) II and IV APIs. In this review we focus the concept of oral fast dissolving films (OFDFs) incorporating nanoparticles (NPs). In this approach a variety of polymers has been used for drug delivery to increase the therapeutic advantages, while minimizing the toxic and the adverse drug effect. Because the NPs present within the nanometer size range protect the APIs against the in vitro and in vivo degradation and improve pharmacokinetic and pharmacodynamic properties of different varieties of drug molecules that are able to achieve targeted delivery. Concomitantly, the dosage forms are available in tablet, capsule, suspension and emulsion form in market, but these are not comfortable for all age group of patients. Depend upon the dose accuracy, patient compliance and therapeutic efficacy the NPs are further incorporated into OFDFs. The OFDFs are superior to oral fast-disintegrating tablets (OFDTs) to overcome the swallowing problem for dysphagia conditions mainly peadiatric and geriatric patients and it provide excellent dissolution profile, periodically convenience of administration, safety and efficacy. There is a huge potential in the market prospect of this innovative pharmaceutical dosage form and it is also targeted.

中文翻译：

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纳米粒子口服速溶膜：药物输送中前瞻性产生的新现实方法

在药物输送中，口服方式是活性药物成分（API）的最理想给药方式，因为它易于管理，可导致高水平的患者依从性。超过50％的API面临着口服分配剂型设计的主要任务，这些剂型的水溶性差，口服生物利用度差，主要是生物制药分类系统（BCS）II和IV API。在这篇综述中，我们关注结合了纳米颗粒（NPs）的口腔快速溶解膜（OFDFs）的概念。在这种方法中，多种聚合物已用于药物递送以增加治疗优势，同时最小化毒性和药物不良作用。因为存在于纳米尺寸范围内的NP保护API免受体外和体内降解并改善能够实现靶向递送的不同种类药物分子的药代动力学和药效学性质。伴随地，这些剂型在市场上以片剂，胶囊剂，混悬剂和乳剂形式可用，但是这些不适用于所有年龄段的患者。取决于剂量的准确性，患者的依从性和治疗效果，NP被进一步掺入OFDF中。OFDF优于口服速崩片（OFDT），可以克服吞咽困难（主要是儿科和老年患者）的吞咽问题，并且溶出度优异，定期给药方便，安全性和有效性。这种创新的药物剂型在市场前景中具有巨大的潜力，并且也有针对性。