In current work, we present 3,6-di(pyridin-2-yl)-1,2,4,5-s-tetrazine (pytz) capped gold nanoparticles (TzAuNPs) as an potent antibacterial agent against Gram-positive bacteria. The antibacterial properties of TzAuNPs have been studied using Gram-positive Bacillus subtilis (ATCC 11774) by the plate count method and TzAuNPs is found to be highly effective against the strain. Furthermore, TzAuNPs also show significantly better antimicrobial activity against the bacterial strain when compared to pytz. The effect of TzAuNPs on the bacterial cell wall is also investigated by TEM analysis. This new antimicrobial material could be promising in future for the treatment infectious diseases caused by Gram-positive bacteria.

中文翻译：

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3,6-二（吡啶-2-基）-1,2,4,5-s-四嗪包覆的金纳米颗粒作为抗革兰氏阳性枯草芽孢杆菌的有效抗菌剂

在当前的工作中，我们提出了3,6-二（吡啶-2-基）-1,2,4,5-s-四嗪（pytz）封端的金纳米颗粒（TzAuNPs），作为针对革兰氏阳性细菌的有效抗菌剂。已经通过平板计数法使用革兰氏阳性枯草芽孢杆菌（ATCC 11774）研究了TzAuNPs的抗菌特性，发现TzAuNPs对菌株具有高度的有效性。此外，与pytz相比，TzAuNPs还对细菌菌株表现出明显更好的抗菌活性。还通过TEM分析研究了TzAuNPs对细菌细胞壁的作用。这种新的抗菌材料将来有望用于治疗革兰氏阳性细菌引起的传染病。