Photocatalytic Decarboxylative [2 + 2 + m] Cyclization of 1,7-Enynes Mediated by Tricyclohexylphosphine and Potassium Iodide,Organic Letters

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Photocatalytic Decarboxylative [2 + 2 + m] Cyclization of 1,7-Enynes Mediated by Tricyclohexylphosphine and Potassium Iodide
Organic Letters ( IF 4.9 ) Pub Date : 2020-11-02 , DOI: 10.1021/acs.orglett.0c03182
Hui-Yuan Liu ₁ , Yuan Lu ₁ , Yang Li ₁ , Jin-Heng Li _{1,

2}

Affiliation

A novel photocatalytic decarboxylative [2 + 2 + m] cyclization of 1,7-enynes with alkyl N-hydroxyphthalimide (NHP) esters, using tricyclohexylphosphine and potassium iodide as redox catalysts, is reported for the construction of functional polycyclic compounds. This protocol tolerates primary, secondary, and tertiary alkyl NHP esters through a single reaction via decarbonylation, radical addition, C–H functionalization, and cyclization under mild conditions.

中文翻译：

三环己基膦和碘化钾介导的1,7-烯炔的光催化脱羧[2 + 2 + m ]环化

据报道，使用三环己基膦和碘化钾作为氧化还原催化剂，用烷基N-羟基邻苯二甲酰亚胺（NHP）酯进行的1,7-烯炔的新型光催化脱羧[2 + 2 + m ]环化反应。该方案通过脱羰，自由基加成，CH-H官能化和在温和条件下环化的单一反应，可以耐受伯，仲和叔烷基NHP酯。

更新日期：2020-11-21

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