Polyunsaturated Fatty Acid Diet and Upregulation of Lipoxin A4 Reduce the Inflammatory Response of Preeclampsia,Journal of Proteome Research

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Polyunsaturated Fatty Acid Diet and Upregulation of Lipoxin A4 Reduce the Inflammatory Response of Preeclampsia
Journal of Proteome Research ( IF 3.8 ) Pub Date : 2020-10-31 , DOI: 10.1021/acs.jproteome.0c00439
Minghui Ou ₁ , Qian Zhang ₂ , Huidong Zhao ₂ , Chang Shu ₃

Affiliation

The aim of this study was to investigate the effects and mechanisms of polyunsaturated fatty acids (PUFAs) and lipoxin A4 (LXA4) on preeclampsia (PE). The LXA4 level was significantly reduced in PE rats. The PUFA diet upregulated the expressions of lipoxygenase 12 (LOX12) and lipoxygenase 15 (LOX15) and downregulated those of cyclooxygenase-2, tumor necrosis factor-α (TNF-α), and endoglin. Lipopolysaccharides could inhibit cell growth and cause inflammatory response, while the presence of PUFAs inhibited the inflammatory response and promoted the expressions of LOX12, LOX15, and LXA4. Nordihydroguaiaretic acid (NDGA) regulated LXA4 expression and inflammation levels by affecting LOX. Inhibition of lipoxygenase 5 activity by NDGA upregulated the expressions of LOX12 and LOX15, while LXA4 reversed LXA4, nitric oxide downregulation, and TNF-α upregulation by NDGA. A decrease in LXA4 levels played an important role in the development and progression of PE.

中文翻译：

多不饱和脂肪酸饮食和Lipoxin A4的上调减少先兆子痫的炎症反应

这项研究的目的是调查多不饱和脂肪酸（PUFAs）和脂蛋白A4（LXA4）对子痫前期（PE）的影响和机制。PE大鼠的LXA4水平明显降低。PUFA饮食上调脂氧合酶12（LOX12）和脂氧合酶15（LOX15）的表达，并下调环氧合酶2，肿瘤坏死因子-α（TNF-α）和内皮糖蛋白的表达。脂多糖可以抑制细胞生长并引起炎症反应，而PUFA的存在抑制炎症反应并促进LOX12，LOX15和LXA4的表达。去甲氢愈创木酸（NDGA）通过影响LOX来调节LXA4表达和炎症水平。NDGA抑制脂氧合酶5的活性上调了LOX12和LOX15的表达，而LXA4逆转了LXA4，一氧化氮的下调，NDGA上调TNF-α。LXA4水平的降低在PE的发展和进程中起着重要作用。

更新日期：2021-01-01

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