The effect of polyvinylpyrrolidone (PVP) as glycyrrhetic acid (GA) solid dispersions carrier at different molecular weights on the dissolution behavior and physicochemical properties was investigated. PVP-GA-SDs prepared with all four molecular weight PVPs displayed good enhancement of dissolution rate and equilibrium solubility compared with pure drug and corresponding physical mixtures. The results showed that the enhancement effect of molecular weight on dissolution rate and equilibrium solubility follows . In addition, the dissolution rate and solubility of the SDs with a carrier-drug ratio of 8 : 1 were better than the samples of 4 : 1. The DSC and XRD patterns showed that the crystallization of GA in SDs prepared by PVP K30 and PVP K60 was significantly inhibited, and both were transformed to amorphous. Based on FTIR and Raman detection, a hydrogen-bond between PVP and drug molecules is formed. SEM results showed that there were no significant differences in the appearance of SDs prepared with four PVPs, and no crystalline morphology of GA was seen. In conclusion, the findings of this study demonstrated that the dissolution performance of the PVP-GA-SDs prepared by the solvent method is related to the molecular weight of PVP, and the change in the molecular weight of PVP does not cause a monotonic change in dissolution of GA. The samples with PVP K30 as the carrier have the best dissolution performance.

中文翻译：

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PVP 分子量对甘草次酸固体分散体溶解行为和理化表征的影响

研究了聚乙烯吡咯烷酮（PVP）作为不同分子量的甘草次酸（GA）固体分散体载体对溶出行为和理化性质的影响。与纯药物和相应的物理混合物相比，用所有四种分子量的 PVP 制备的 PVP-GA-SD 显示出良好的溶出率和平衡溶解度。结果表明，分子量对溶解速率和平衡溶解度的增强作用如下。此外，载体药物比为 8:1 的 SDs 的溶出速率和溶解度优于 4:1 的样品。 DSC 和 XRD 谱表明，PVP K30 和 PVP 制备的 SDs 中的 GA 结晶K60 被显着抑制，两者都转化为无定形。基于FTIR和拉曼检测，PVP与药物分子之间形成氢键。SEM 结果表明，四种 PVP 制备的 SDs 的外观没有显着差异，并且没有观察到 GA 的结晶形态。综上所述，本研究结果表明，溶剂法制备的 PVP-GA-SDs 的溶出性能与 PVP 的分子量有关，PVP 分子量的变化不会引起 PVP 的单调变化。 GA 的溶解。以PVP K30为载体的样品溶出性能最好。本研究结果表明，溶剂法制备的 PVP-GA-SDs 的溶出性能与 PVP 的分子量有关，PVP 分子量的变化不会导致 GA 的溶出度发生单调变化. 以PVP K30为载体的样品溶出性能最好。本研究结果表明，溶剂法制备的 PVP-GA-SDs 的溶出性能与 PVP 的分子量有关，PVP 分子量的变化不会导致 GA 的溶出度发生单调变化. 以PVP K30为载体的样品溶出性能最好。