Atherosclerosis is nowadays recognized as a chronic inflammatory disease of large arteries. In recent years, cellular and molecular biology studies on atherosclerosis confirmed that the occurrence and development are related to inflammation and autoimmunity. A variety of immune cells, cytokines, and transcription factors are involved in this process. Current studies found that T helper cell 17, regulatory T cells, and their cytokines play an important role in the development of atherosclerosis and vulnerable plaque rupture. Here, we provide a review of the up-to-date applications of T helper cell 17, regulatory T cells, cytokines, and their balance in the prognosis and therapy of atherosclerosis.

中文翻译：

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Th17/Treg 失衡与动脉粥样硬化

如今，动脉粥样硬化被认为​​是一种大动脉的慢性炎症性疾病。近年来，动脉粥样硬化的细胞和分子生物学研究证实其发生发展与炎症和自身免疫有关。这一过程涉及多种免疫细胞、细胞因子和转录因子。目前的研究发现，辅助性 T 细胞 17、调节性 T 细胞及其细胞因子在动脉粥样硬化和易损斑块破裂的发展中起着重要作用。在这里，我们回顾了 T 辅助细胞 17、调节性 T 细胞、细胞因子及其在动脉粥样硬化预后和治疗中的平衡的最新应用。