Purpose. To calculate the diagnostic value of C-reactive protein (CRP) and serum procalcitonin (PCT) levels for the pathologic presence of microbes in the bloodstream of patients with malignancy, in comparison with blood culture. Methodology. Blood culture (by reference method) and assay results of PCT and CRP of febrile patients, with clinical suspicion to blood infections, were collected. Statistical aspects of PCT and CRP tests were evaluated. Results. Data from 255 cases were gathered. The area under the curve for differentiating bacteremia from nonbacteremia for PCT (0.741) was superior to that of CRP (0.612). Amongst the different cutoffs of PCT and CRP, the cutoff of ≥1.17 ng/ml and >47 mg/l had the sensitivity of 75 and 58.3%, the best NPV of 91.5% and 81.3%, and the best specificity of 79.9% and 72.8%, respectively. Discussion. Despite statistically nonsignificant results, PCT seems to be a superior indicator to CRP for rejecting the presence of microorganism in bloodstream. For PCT, the cutoff value of 1.17 ng/ml (bacteremia from nonbacteremia) had the highest NPV value of 91.5% in malignant patients, suspicion of sepsis.

中文翻译：

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用于准确诊断恶性肿瘤患者血流感染的免疫生物标志物的诊断准确性：降钙素原与 C 反应蛋白的比较

目的。计算 C 反应蛋白 (CRP) 和血清降钙素原 (PCT) 水平对恶性肿瘤患者血流中微生物病理存在的诊断价值，并与血培养进行比较。方法论。收集临床怀疑为血液感染的发热患者的血培养（参照法）和PCT、CRP检测结果。PCT 和 CRP 测试的统计方面进行了评估。结果. 收集了 255 个病例的数据。PCT（0.741）区分菌血症和非菌血症的曲线下面积优于CRP（0.612）。在PCT和CRP的不同临界值中，≥1.17 ng/ml和>47 mg/l的临界值敏感性分别为75%和58.3%，最佳NPV分别为91.5%和81.3%，最佳特异性分别为79.9%和分别为 72.8%。讨论。尽管统计上不显着的结果，PCT 似乎是一个优于 CRP 的指标，用于拒绝血液中微生物的存在。对于 PCT，1.17 ng/ml（非菌血症的菌血症）的临界值在恶性患者中的 NPV 值最高，为 91.5%，怀疑是败血症。