离子液体介导的红色发射碳点的优化及其在活细胞中的成像应用,ACS Sustainable Chemistry & Engineering

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离子液体介导的红色发射碳点的优化及其在活细胞中的成像应用
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-11-02 , DOI: 10.1021/acssuschemeng.0c07209
Yuhua Zhang ₁ , Yongguang Wu ₂ , Jing Wang ₁ , Ye Hu ₁ , Wenhui Fang ₁ , Jiaqi Dang ₁ , Ying Wu ₁ , Xiangjun Li ₁ , Hong Zhao ₁ , Zengxi Li ₁

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最近，就其独特的光学特性，强大的化学惰性和出色的生物相容性而言，荧光碳点（CD）已成为新型碳纳米材料。然而，由于其比不具有低波长发射的CD更深的组织穿透力和更大的生物成像能力，合成高效的红色发射碳点（R-CD）对于传感应用，特别是在生物成像领域仍然非常需要。在此，通过一步溶剂热处理o合成了新型R-CD 。-苯二胺和离子液体1-丁基-3-甲基咪唑六氟磷酸盐。所制备的R-CD显示出显着的嗜酸能力。结果表明，R-CDs在620 nm处的荧光强度随pH从1.5增加到6.0以及对极端酸度范围1.5–4.0的线性响应而降低。重要的是，它对pH响应的敏感性是磷酸盐介导的R-CD的4.7倍。提议的pH传感器进一步应用于监测大肠杆菌（E. coli）中的极端pH波动）。与那些具有低波长发射的CD相比，离子液体介导的R-CD具有更低的能量，更强的渗透性和更大的生物成像能力，使其更适合生物和医学应用。据我们所知，到目前为止，尚无离子液体介导的R-CD的报道，这将开启用离子液体合成R-CD的新篇章。

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Optimization of Ionic Liquid-Mediated Red-Emission Carbon Dots and Their Imaging Application in Living Cells

Recently, fluorescent carbon dots (CDs) have emerged as novel carbon nanomaterials in terms of their unique optical properties, robust chemical inertness, and excellent biocompatibility. However, synthesis of efficient red-emission carbon dots (R-CDs) remains highly desirable for sensing applications, especially in the field of bioimaging, on account of their deeper tissue penetration and greater bioimaging capability than CDs with low-wavelength emission. Herein, novel R-CDs are synthesized by one-step solvothermal treatment of o-phenylenediamine and the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate. The as-prepared R-CDs exhibit remarkable acidophilic ability; the results show that the fluorescence intensity of R-CDs at 620 nm decreases with increasing pH from 1.5 to 6.0 and with a linear response to the extreme acidity range of 1.5–4.0. Importantly, it is nearly 4.7-fold more sensitive to pH response than phosphate-mediated R-CDs. The proposed pH sensor is further applied to monitor extreme pH fluctuations in Escherichia coli (E. coli). Compared to those CDs with low-wavelength emission, ionic liquid-mediated R-CDs have lower energy, stronger penetrability, and greater bioimaging capabilities, making them more preferable for biological and medical applications. To our knowledge, no R-CDs mediated by ionic liquids are reported until now, which would open a new chapter in the synthesis of R-CDs with ionic liquids.

更新日期：2020-11-16

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