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Optimization of Ionic Liquid-Mediated Red-Emission Carbon Dots and Their Imaging Application in Living Cells
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-11-02 , DOI: 10.1021/acssuschemeng.0c07209 Yuhua Zhang 1 , Yongguang Wu 2 , Jing Wang 1 , Ye Hu 1 , Wenhui Fang 1 , Jiaqi Dang 1 , Ying Wu 1 , Xiangjun Li 1 , Hong Zhao 1 , Zengxi Li 1
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-11-02 , DOI: 10.1021/acssuschemeng.0c07209 Yuhua Zhang 1 , Yongguang Wu 2 , Jing Wang 1 , Ye Hu 1 , Wenhui Fang 1 , Jiaqi Dang 1 , Ying Wu 1 , Xiangjun Li 1 , Hong Zhao 1 , Zengxi Li 1
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Recently, fluorescent carbon dots (CDs) have emerged as novel carbon nanomaterials in terms of their unique optical properties, robust chemical inertness, and excellent biocompatibility. However, synthesis of efficient red-emission carbon dots (R-CDs) remains highly desirable for sensing applications, especially in the field of bioimaging, on account of their deeper tissue penetration and greater bioimaging capability than CDs with low-wavelength emission. Herein, novel R-CDs are synthesized by one-step solvothermal treatment of o-phenylenediamine and the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate. The as-prepared R-CDs exhibit remarkable acidophilic ability; the results show that the fluorescence intensity of R-CDs at 620 nm decreases with increasing pH from 1.5 to 6.0 and with a linear response to the extreme acidity range of 1.5–4.0. Importantly, it is nearly 4.7-fold more sensitive to pH response than phosphate-mediated R-CDs. The proposed pH sensor is further applied to monitor extreme pH fluctuations in Escherichia coli (E. coli). Compared to those CDs with low-wavelength emission, ionic liquid-mediated R-CDs have lower energy, stronger penetrability, and greater bioimaging capabilities, making them more preferable for biological and medical applications. To our knowledge, no R-CDs mediated by ionic liquids are reported until now, which would open a new chapter in the synthesis of R-CDs with ionic liquids.
中文翻译：
离子液体介导的红色发射碳点的优化及其在活细胞中的成像应用
最近，就其独特的光学特性，强大的化学惰性和出色的生物相容性而言，荧光碳点（CD）已成为新型碳纳米材料。然而，由于其比不具有低波长发射的CD更深的组织穿透力和更大的生物成像能力，合成高效的红色发射碳点（R-CD）对于传感应用，特别是在生物成像领域仍然非常需要。在此，通过一步溶剂热处理o合成了新型R-CD 。-苯二胺和离子液体1-丁基-3-甲基咪唑六氟磷酸盐。所制备的R-CD显示出显着的嗜酸能力。结果表明，R-CDs在620 nm处的荧光强度随pH从1.5增加到6.0以及对极端酸度范围1.5–4.0的线性响应而降低。重要的是，它对pH响应的敏感性是磷酸盐介导的R-CD的4.7倍。提议的pH传感器进一步应用于监测大肠杆菌（E. coli）中的极端pH波动）。与那些具有低波长发射的CD相比，离子液体介导的R-CD具有更低的能量，更强的渗透性和更大的生物成像能力，使其更适合生物和医学应用。据我们所知，到目前为止，尚无离子液体介导的R-CD的报道，这将开启用离子液体合成R-CD的新篇章。
更新日期：2020-11-16
中文翻译：
离子液体介导的红色发射碳点的优化及其在活细胞中的成像应用
最近，就其独特的光学特性，强大的化学惰性和出色的生物相容性而言，荧光碳点（CD）已成为新型碳纳米材料。然而，由于其比不具有低波长发射的CD更深的组织穿透力和更大的生物成像能力，合成高效的红色发射碳点（R-CD）对于传感应用，特别是在生物成像领域仍然非常需要。在此，通过一步溶剂热处理o合成了新型R-CD 。-苯二胺和离子液体1-丁基-3-甲基咪唑六氟磷酸盐。所制备的R-CD显示出显着的嗜酸能力。结果表明，R-CDs在620 nm处的荧光强度随pH从1.5增加到6.0以及对极端酸度范围1.5–4.0的线性响应而降低。重要的是，它对pH响应的敏感性是磷酸盐介导的R-CD的4.7倍。提议的pH传感器进一步应用于监测大肠杆菌（E. coli）中的极端pH波动）。与那些具有低波长发射的CD相比，离子液体介导的R-CD具有更低的能量，更强的渗透性和更大的生物成像能力，使其更适合生物和医学应用。据我们所知，到目前为止，尚无离子液体介导的R-CD的报道，这将开启用离子液体合成R-CD的新篇章。
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