Decades of research efforts have conclusively provided overwhelming evidence that the cellular prion protein (PrP^C) plays a central role in prion diseases, a set of fatal and incurable neurodegenerative disorders for which no therapy is yet available. In this Viewpoint, we provide an overview of the drug discovery strategies in the field, highlighting the current therapeutic hypotheses targeting, whether directly or indirectly, PrP^C as well as the antiprion agents closest to clinical application.

中文翻译：

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迫切需要针对PrC ^C的有效的针对Prion疾病的疗法

数十年的研究努力最终提供了压倒性的证据，表明细胞ion病毒蛋白（PrP ^C）在ion病毒疾病中起着中心作用，,病毒疾病是一组致命且无法治愈的神经退行性疾病，目前尚无治疗方法。在此观点中，我们概述了该领域的药物发现策略，突出了当前针对治疗性假说的目标，无论是直接还是间接针对PrP ^C以及最接近临床应用的抗pr病毒剂。