We report a patient with severe Covid-19-associated coagulopathy and type 2 diabetes mellitus who tested positive for antiphospholipid antibodies (aPL). Analysis of skin specimens suggested direct SARS-CoV-2 viral-induced and complement-mediated vascular injury and thrombosis, consistent with prior reports. Serial aPL testing demonstrated high levels of anticardiolipin antibodies (aCL) that declined to insignificant levels over a period of 5 weeks. SARS-CoV-2 RNA was detected in nasopharyngeal swab specimens on serial assays performed over the same 5-week period, though it was not detected thereafter. We hypothesize that SARS-CoV-2 viral-induced aPL contributed to severe Covid-19-associated coagulopathy in this patient.

中文翻译：

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一名患有补体介导的凝血病和严重血栓形成的 Covid-19 患者

我们报告了一名患有严重 Covid-19 相关凝血病和 2 型糖尿病的患者，其抗磷脂抗体 (aPL) 检测呈阳性。对皮肤标本的分析表明直接由 SARS-CoV-2 病毒引起和补体介导的血管损伤和血栓形成，与之前的报告一致。连续 aPL 测试显示高水平的抗心磷脂抗体 (aCL) 在 5 周内下降到不显着的水平。在相同的 5 周内进行的系列化验中，在鼻咽拭子标本中检测到了 SARS-CoV-2 RNA，但此后未检测到。我们假设 SARS-CoV-2 病毒诱导的 aPL 导致了该患者严重的 Covid-19 相关凝血病。