Abstract Polylactic acid (PLA) is one of the most commonly used materials in the biomedical sector because of its processability, mechanical properties and biocompatibility. Among the different techniques that are feasible to process this biomaterial, additive manufacturing (AM) has gained attention recently, as it provides the possibility of tuning the design of the structures. This flexibility in the design stage allows the customization of the parts in order to optimize their use in the tissue engineering field. In the recent years, the application of PLA for the manufacture of bone scaffolds has been especially relevant, since numerous studies have proven the potential of this biomaterial for bone regeneration. This review contains a description of the specific requirements in the regeneration of bone and how the state of the art have tried to address them with different strategies to develop PLA-based scaffolds by AM techniques and with improved biofunctionality.

中文翻译：

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用于骨再生的 PLA 基支架的增材制造和改善其生物学特性的策略

摘要 聚乳酸（PLA）因其可加工性、机械性能和生物相容性而成为生物医学领域最常用的材料之一。在可用于处理这种生物材料的不同技术中，增材制造 (AM) 最近受到关注，因为它提供了调整结构设计的可能性。设计阶段的这种灵活性允许对部件进行定制，以优化它们在组织工程领域的使用。近年来，PLA 在骨支架制造中的应用尤为重要，因为大量研究已经证明了这种生物材料在骨再生方面的潜力。