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Piperine-Coated Gold Nanoparticles Alleviate Paraquat-Induced Neurotoxicity in Drosophila melanogaster
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-10-30 , DOI: 10.1021/acschemneuro.0c00366 Saurabh Srivastav 1 , Bibin G Anand 1 , Mahino Fatima 1 , Kailash P Prajapati 1 , Suresh Singh Yadav 1 , Karunakar Kar 1 , Amal Chandra Mondal 1
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-10-30 , DOI: 10.1021/acschemneuro.0c00366 Saurabh Srivastav 1 , Bibin G Anand 1 , Mahino Fatima 1 , Kailash P Prajapati 1 , Suresh Singh Yadav 1 , Karunakar Kar 1 , Amal Chandra Mondal 1
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Parkinson’s disease (PD) is the most common progressive neurodegenerative disease known to impart bradykinesia leading to diverse metabolic complications. Currently, scarcity of effective drug candidates against this long-term devastating disorder poses a big therapeutic challenge. Here, we have synthesized biocompatible, polycrystalline, and uniform piperine-coated gold nanoparticles (AuNPspiperine) to specifically target paraquat-induced metabolic complications both in Drosophila melanogaster and SH-SY5Y cells. Our experimental evidence clearly revealed that AuNPspiperine can effectively reverse paraquat-induced lethal effects in both in vitro and in vivo model systems of PD. AuNPspiperine were found to suppress oxidative stress and mitochondrial dysfunction, leading to inhibition of apoptotic cell death in paraquat-treated flies. AuNPspiperine were also found to protect SH-SY5Y cells against paraquat-induced toxicity at the cellular level preferably by maintaining mitochondrial membrane potential. Both experimental and computational data point to the possible influence of AuNPspiperine in regulating the homeostasis of parkin and p53 which may turn out to be the key factors in reducing PD symptoms. The findings of this work may facilitate the development of piperine-based nanoformulations against PD.
中文翻译：
胡椒碱包被的金纳米颗粒减轻百草枯引起的果蝇黑果神经毒性。
帕金森氏病（PD）是最常见的进行性神经退行性疾病，已知会引起运动迟缓，导致各种代谢并发症。当前，针对这种长期破坏性疾病的有效候选药物的缺乏提出了巨大的治疗挑战。在这里，我们已经合成了生物相容的，多晶的，均匀的胡椒碱包被的金纳米颗粒（AuNPs piperine），专门针对百草枯引起的果蝇和SH-SY5Y细胞中的代谢并发症。我们的实验证据清楚地表明，金纳米粒子胡椒碱能有效逆转百草枯诱导的两个致命的影响在体外和体内PD模型系统。AuNPs胡椒碱被发现抑制氧化应激和线粒体功能障碍，从而导致百草枯处理的果蝇凋亡细胞死亡的抑制。还发现AuNPs胡椒碱优选通过维持线粒体膜电位来在细胞水平上保护SH-SY5Y细胞免受百草枯诱导的毒性。实验和计算数据均表明AuNPs胡椒碱在调节帕金和p53稳态中的可能作用，这可能是减轻PD症状的关键因素。这项工作的发现可能有助于开发针对胡椒的基于胡椒碱的纳米制剂。
更新日期：2020-11-18
中文翻译：
胡椒碱包被的金纳米颗粒减轻百草枯引起的果蝇黑果神经毒性。
帕金森氏病（PD）是最常见的进行性神经退行性疾病，已知会引起运动迟缓，导致各种代谢并发症。当前，针对这种长期破坏性疾病的有效候选药物的缺乏提出了巨大的治疗挑战。在这里，我们已经合成了生物相容的，多晶的，均匀的胡椒碱包被的金纳米颗粒（AuNPs piperine），专门针对百草枯引起的果蝇和SH-SY5Y细胞中的代谢并发症。我们的实验证据清楚地表明，金纳米粒子胡椒碱能有效逆转百草枯诱导的两个致命的影响在体外和体内PD模型系统。AuNPs胡椒碱被发现抑制氧化应激和线粒体功能障碍，从而导致百草枯处理的果蝇凋亡细胞死亡的抑制。还发现AuNPs胡椒碱优选通过维持线粒体膜电位来在细胞水平上保护SH-SY5Y细胞免受百草枯诱导的毒性。实验和计算数据均表明AuNPs胡椒碱在调节帕金和p53稳态中的可能作用，这可能是减轻PD症状的关键因素。这项工作的发现可能有助于开发针对胡椒的基于胡椒碱的纳米制剂。
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