Abstract

Objectives

The aim of our study was to evaluate the effects of low and high-frequency repetitive transcranial magnetic stimulation (rTMS) on hypoxia-induced changes in bilateral cerebrovascular reserve up to 24 h in the same individuals.

Methods

Right-handed ten healthy male individuals participated in the study. All participants had neither drug therapy nor a concomitant disease and none of them had a variation in the circle of Willis, intracranial stenosis, arteriovenous malformation, or aneurysm which may have an impact on transcranial doppler ultrasound (TCD) examination and transcranial magnetic stimulation (TMS) recording.

Results

There was a statistically significant difference in the breath‐holding index (BHI) between before and after 0, 15, 30 min after 1 Hz repetitive stimulation (p < 0.05). When applying 5 Hz repetitive stimulation there was no difference before and after BHI values (p > 0.05). There were no differences in bilateral, ipsilateral, or contralateral middle cerebral artery (MCA) mean cerebral blood flow velocity (CBFV) after low or high-frequency rTMS application (p > 0.05).

Conclusion

The main result of the study was that low-frequency rTMS reduced vasomotor reactivity (VMR) for the very first 30 min and then this effect disappears. And the high-frequency rTMS did not affect VMR at all.

Significance

The effect of rTMS on VMR may continue up to 30 min but then return to the baseline and can be used safely.

中文翻译：

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哪种重复经颅磁刺激方式会影响健康受试者的血管舒缩反应性，​​持续多长时间？

摘要

目标

我们研究的目的是评估低频和高频重复经颅磁刺激 (rTMS) 对同一个体长达 24 小时的缺氧引起的双侧脑血管储备变化的影响。

方法

右手十名健康男性参加了这项研究。所有参与者均未接受药物治疗或合并疾病，均未出现可能影响经颅多普勒超声（TCD）检查和经颅磁刺激（TMS）的 Willis 环变异、颅内狭窄、动静脉畸形或动脉瘤。 ） 记录。

结果

在 1 Hz 重复刺激后 0、15、30 分钟之前和之后的屏气指数（BHI）存在统计学上的显着差异（p  < 0.05）。当应用 5 Hz 重复刺激时，BHI 值前后没有差异 ( p  > 0.05)。低频或高频 rTMS 应用后双侧、同侧或对侧大脑中动脉 (MCA) 平均脑血流速度 (CBFV) 没有差异 ( p  > 0.05)。

结论

该研究的主要结果是低频 rTMS 在最初的 30 分钟内降低了血管舒缩反应性 (VMR)，然后这种影响消失了。并且高频 rTMS 根本不影响 VMR。

意义

rTMS 对 VMR 的影响可能会持续长达 30 分钟，但随后会恢复到基线并可以安全使用。