Abstract

Purpose

Although both motor symptoms and non-motor symptoms (NMSs) occur in patients with Parkinson's disease (PD), clinical practice focuses more on motor symptoms. The aim of this study was to examine balance, muscle strength, and mobility in relation with NMSs in patients with PD. The other aim of this study was to investigate the relationship between NMSs and muscle strength, balance, and functional mobility in PD.

Materials and methods

The study included 24 patients with PD (between Hoehn & Yahr Stage 1 and 3) and 20 healthy individuals of similar age and sex. The participants' balance was assessed with the Biodex Balance System (Biodex Medical Systems, Shirley, NY, USA), muscle strength assessments were conducted with a Biodex^® System 4 Dynamometer device, and functional mobility was assessed with the Timed Up and Go test (TUG). The non-motor symptoms scale was used for NMSs.

Results

We found that lower extremity strength scores were lower and NMSs, balance, and mobility scores were greater in patients with PD in comparison to healthy controls (p < 0.05). The correlation analysis revealed that higher NMSs were related to reduced knee extension strength and cognitive dual task performance.

Conclusion

Although no relationship between NMSs and balance was observed, the relationship between the TUG + cognitive task and muscle strength suggests that NMSs should be carefully evaluated along with the motor symptoms, which deteriorate beginning with the early period.

中文翻译：

---

帕金森病患者非运动症状、平衡、肌肉力量和功能活动能力的调查

摘要

目的

尽管帕金森病 (PD) 患者会出现运动症状和非运动症状 (NMS)，但临床实践更多地关注运动症状。本研究的目的是检查与 PD 患者的 NMS 相关的平衡、肌肉力量和活动能力。本研究的另一个目的是研究 NMS 与 PD 中肌肉力量、平衡和功能流动性之间的关系。

材料和方法

该研究包括 24 名 PD 患者（介于 Hoehn 和 Yahr 阶段 1 和 3 之间）和 20 名年龄和性别相似的健康个体。参与者的平衡使用 Biodex 平衡系统（Biodex Medical Systems, Shirley, NY, USA）进行评估，肌肉力量评估使用 Biodex ^® System 4 测功机设备进行，功能移动性使用 Timed Up and Go 测试进行评估（拖船）。非运动症状量表用于 NMS。

结果

我们发现，与健康对照组相比，PD 患者的下肢力量评分较低，NMS、平衡和活动能力评分较高（p  < 0.05）。相关性分析表明，较高的 NMS 与膝关节伸展强度和认知双重任务表现降低有关。

结论

尽管未观察到 NMS 与平衡之间的关系，但 TUG + 认知任务与肌肉力量之间的关系表明，应仔细评估 NMS 以及从早期开始恶化的运动症状。