ABSTRACT Spliceosomes are large complexes regulating pre-mRNA processing in eukaryotes. Arabidopsis JANUS encodes a putative subunit of spliceosome`. We recently demonstrated that JANUS plays an essential role during early embryogenesis and root meristem development. Instead of mediating pre-mRNA splicing as a subunit of spliceosome, JANUS regulates the transcription of key genes by recruiting RNA Polymerase II (Pol II). Here, we summarize our latest findings and provide insights into the regulation of JANUS during Arabidopsis development.

中文翻译：

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剪接体成分 JANUS 在拟南芥发育过程中发挥介体在转录调控中的作用

摘要 剪接体是调节真核生物中前体 mRNA 加工的大型复合物。拟南芥 JANUS 编码一个假定的剪接体亚基。我们最近证明 JANUS 在早期胚胎发生和根分生组织发育过程中起着至关重要的作用。JANUS 通过招募 RNA 聚合酶 II (Pol II) 来调节关键基因的转录，而不是将前 mRNA 剪接作为剪接体的一个亚基进行调节。在这里，我们总结了我们的最新发现，并提供了对拟南芥发育过程中 JANUS 调控的见解。