Characterization and protective efficacy of a sptP mutant of Salmonella Paratyphi A,Immunity, Inflammation and Disease

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Characterization and protective efficacy of a sptP mutant of Salmonella Paratyphi A
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2020-11-01 , DOI: 10.1002/iid3.369
Pengtao Pan ₁ , Fanyu Zou ₁ , Chuanshan He ₂ , Qunli He ₃ , Junlei Yin ₁

Affiliation

Salmonella Paratyphi A causes paratyphoid A, a severe systemic disease of people and remains a major public health problem in many parts of the world. In the interest of researching the roles of sptP on Salmonella Paratyphi A and developing a live‐attenuated vaccine candidate, an sptP mutant of Salmonella Paratyphi A SPA017 (SPA017ΔsptP) was constructed, and then its characterization, immunogenicity, and protective ability were evaluated.

中文翻译：

甲型副伤寒沙门氏菌 sptP 突变体的表征和保护功效

甲型副伤寒沙门氏菌引起甲型副伤寒，这是一种严重的全身性疾病，在世界许多地方仍然是一个主要的公共卫生问题。为了研究sptP对甲型副伤寒沙门氏菌的作用并开发减毒活疫苗候选物，构建了副伤寒沙门氏菌SPA017 (SPA017Δ sptP )的sptP突变体，然后对其表征、免疫原性和保护能力进行了评估。

更新日期：2020-11-12

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