Inhibition of deubiquitination by PR‐619 induces apoptosis and autophagy via ubi‐protein aggregation‐activated ER stress in oesophageal squamous cell carcinoma,Cell Proliferation

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Inhibition of deubiquitination by PR‐619 induces apoptosis and autophagy via ubi‐protein aggregation‐activated ER stress in oesophageal squamous cell carcinoma
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-10-31 , DOI: 10.1111/cpr.12919
Longhao Wang ₁ , Miaomiao Li ₁ , Beibei Sha ₁ , Xuanyu Hu ₁ , Yaxin Sun ₁ , Mingda Zhu ₁ , Yan Xu ₁ , Pingping Li ₁ , Yating Wang ₁ , Yanyan Guo ₁ , Jiangfeng Li ₁ , Jianxiang Shi ₂ , Pei Li ₁ , Tao Hu ₁ , Ping Chen _{1,

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Affiliation

Targeting the deubiquitinases (DUBs) has become a promising avenue for anti‐cancer drug development. However, the effect and mechanism of pan‐DUB inhibitor, PR‐619, on oesophageal squamous cell carcinoma (ESCC) cells remain to be investigated.

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