ABC‐F translation factors: from antibiotic resistance to immune response,FEBS Letters

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ABC‐F translation factors: from antibiotic resistance to immune response
FEBS Letters ( IF 3.0 ) Pub Date : 2020-12-04 , DOI: 10.1002/1873-3468.13984
Corentin R Fostier ₁ , Laura Monlezun ₁ , Farès Ousalem ₁ , Shikha Singh ₂ , John F Hunt ₂ , Grégory Boël ₁

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Energy-dependent Translational Throttle A (EttA) from E. coli is a paradigmatic ABC-F protein that controls the first step in polypeptide elongation on the ribosome according to the cellular energy status. Biochemical and structural studies have established that ABC-F proteins generally function as translation factors that modulate the conformation of the peptidyl transferase center upon binding to the ribosomal tRNA exit site. These factors, present in both prokaryotes and eukaryotes but not in archaea, use related molecular mechanisms to modulate protein synthesis for heterogenous purposes, ranging from antibiotic resistance and rescue of stalled ribosomes to modulation of the mammalian immune response. Here we review the canonical studies characterizing the phylogeny, regulation, ribosome interactions, and mechanisms of action of the bacterial ABC-F proteins, and discuss the implications of these studies for the molecular function of eukaryotic ABC-F proteins, including the three human family members.

中文翻译：

ABC-F 翻译因子：从抗生素耐药性到免疫反应

来自大肠杆菌的能量依赖性转化节流阀 A (EttA) 是一种典型的 ABC-F 蛋白，它根据细胞能量状态控制核糖体上多肽延伸的第一步。生化和结构研究已经确定，ABC-F 蛋白通常作为翻译因子发挥作用，在与核糖体 tRNA 出口位点结合后调节肽基转移酶中心的构象。这些因素存在于原核生物和真核生物中，但不存在于古生菌中，它们使用相关的分子机制来调节蛋白质合成，以实现不同的目的，从抗生素抗性和拯救停滞的核糖体到调节哺乳动物的免疫反应。在这里，我们回顾了描述系统发育、调控、核糖体相互作用的典型研究，

更新日期：2020-12-04

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