Post‐transcriptional regulation of ATP‐binding cassette (ABC) proteins has been so far shown to encompass protein phosphorylation, maturation, and ubiquitination. Yet, recent accumulating evidence implicates FK506‐binding proteins (FKBPs), a type of peptidylprolyl cis–trans isomerase (PPIase) proteins, in ABC transporter regulation. In this perspective article, we summarize current knowledge on ABC transporter regulation by FKBPs, which seems to be conserved over kingdoms and ABC subfamilies. We uncover striking functional similarities but also differences between regulatory FKBP‐ABC modules in plants and mammals. We dissect a PPIase‐ and HSP90‐dependent and independent impact of FKBPs on ABC biogenesis and transport activity. We propose and discuss a putative new mode of transient ABC transporter regulation by cis–trans isomerization of X‐prolyl bonds.

中文翻译：

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ABC 中的一个转折：FK506 结合蛋白对 ABC 转运蛋白运输和转运的调节

迄今为止，ATP 结合盒 (ABC) 蛋白的转录后调控已被证明包括蛋白磷酸化、成熟和泛素化。然而，最近越来越多的证据表明 FK506 结合蛋白 (FKBPs)，一种肽基脯氨酰顺反异构酶 (PPIase) 蛋白，参与了 ABC 转运蛋白的调节。在这篇观点文章中，我们总结了 FKBPs 对 ABC 转运蛋白调节的当前知识，这似乎在王国和 ABC 亚科中是保守的。我们发现了植物和哺乳动物中调节 FKBP-ABC 模块之间惊人的功能相似性和差异。我们剖析了 FKBPs 对 ABC 生物发生和运输活动的 PPIase 和 HSP90 依赖性和独立影响。