Published radiotherapy results for suspected heart‐based tumours in dogs are limited. In this retrospective longitudinal study (3/2014‐2019), eight dogs with either clinical signs attributable to a heart‐base mass (6), or asymptomatic with a progressively larger mass on echocardiogram (2), received conventional fractionated radiotherapy (CFRT) or stereotactic body radiotherapy (SBRT). Clinical findings in symptomatic cases included one or more of the following: retching/coughing (4), exercise intolerance (2), collapse (1), pericardial effusion (2), rare ventricular premature contractions (2), abdominal effusion (1), or respiratory distress due to chylothorax (1). CFRT cases received 50 Gray (Gy) in 20 fractions and SBRT cases received 30 Gy in 5 or 24 Gy in three fractions. Two dogs received chemotherapy post‐radiation. At analysis, 7/8 dogs were deceased and one was alive 684 days post‐treatment. The estimated median overall survival (MOS) from first treatment was 785 days (95% CI 114‐868 days, [range 114‐1492 days]). Five dogs received CFRT (MOS 817 days; (95% CI 155 days‐not reached [range 155‐1492 days])). Three dogs received SBRT with one alive at analysis (MOS 414 days, (95% CI, 114 days‐not reached [range 114‐414 days])). No statistically significant difference was found between survival for CFRT and SBRT. Of the symptomatic patients, 5/6 showed improvement. Mass size reduced in 4/5 cases receiving follow‐up ultrasounds. Possible complications included asymptomatic radiation pneumonitis (4), atrial tachycardia/premature beats (4) and pericardial effusion with heart failure coincident with tumour progression (1). This study provides preliminary evidence that radiotherapy may impact clinically relevant or progressively enlarging heart‐base masses.

中文翻译：

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犬疑似心底肿瘤的常规分割和立体定向放射治疗的长期结果

已发表的犬疑似心脏肿瘤的放射治疗结果有限。在这项回顾性纵向研究 (3/2014-2019) 中，八只具有可归因于心脏基底肿块的临床症状 (6) 或无症状且超声心动图上肿块逐渐增大 (2) 的狗接受了常规分割放疗 (CFRT)或立体定向放射治疗 (SBRT)。有症状病例的临床发现包括以下一项或多项：干呕/咳嗽 (4)、运动不耐受 (2)、虚脱 (1)、心包积液 (2)、罕见的室性早搏 (2)、腹腔积液 (1) ，或因乳糜胸引起的呼吸窘迫 (1)。CFRT 病例接受 50 格雷 (Gy) 分 20 次照射，SBRT 病例接受 30 Gy 5 或 24 Gy 分三次照射。两只狗在放疗后接受了化疗。分析时，7/8 只狗死亡，其中一只在治疗后 684 天还活着。第一次治疗的估计中位总生存期 (MOS) 为 785 天（95% CI 114-868 天，[范围 114-1492 天]）。五只狗接受了 CFRT（MOS 817 天；（95% CI 155 天-未达到 [范围 155-1492 天]））。三只狗接受了 SBRT，其中一只在分析时还活着（MOS 414 天，（95% CI，114 天-未达到 [范围 114-414 天]））。在 CFRT 和 SBRT 的生存率之间没有发现统计学上的显着差异。在有症状的患者中，5/6 表现出改善。4/5 病例接受随访超声后肿块缩小。可能的并发症包括无症状放射性肺炎 (4)、房性心动过速/早搏 (4) 和心包积液伴有心力衰竭与肿瘤进展 (1)。