Ethanol‐soluble proteins from the royal jelly of Xinjiang black bees,Protein Science

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Ethanol‐soluble proteins from the royal jelly of Xinjiang black bees
Protein Science ( IF 8 ) Pub Date : 2020-11-01 , DOI: 10.1002/pro.3985
Yanyan Yuan ₁ , Wujun Wang ₁ , Ruru Fan ₁ , Jianhui Jiang ₂ , Shan Feng ₃ , Huiwei Yin ₁ , Shi-Zhong Luo ₁ , Long Chen ₁

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Royal jelly is a nutritious food that has beneficial effects to human health. However, the functional substances remain unclear. Herein, we fractioned the royal jelly proteins of Xinjing black bees according to the Osboren method. Two main proteins from the ethanol‐soluble fraction were purified and identified. RJG‐1 was determined as glucosylceramidase, and RJG‐2 was major royal jelly protein 1 (MRJP1). RJG‐1 showed potent cytotoxicity toward various mammalian cells, and caused quick disruption of cell membranes. With glucosylceramidase activity, RJG‐1 may degrade the glucosylceramide of the cell membranes and disrupt the membrane structure, thereby resulting in cell necrosis. This study extends our knowledge about the composition and function of royal jelly, and is significant for the application of royal jelly.

更新日期：2021-01-05

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