The synergistic tumor therapy in single nanoplatform has always been the goal for high efficacy tumor treatment while still remains great challenge. This paper reports a versatile nanotheranostic platform enlisting magnetic iron oxide nanoparticles, polydopamine (PDA), gold nanocages (Au nanocage) and metal organic framework (MOF, MIL101‐NH₂) in order to achieve synergistic chemothermal tumor therapy both in vitro and in vivo. The prepared magnetic photothermal nanoparticles (MPNPs) exhibit high drug loading capacity (31.34 mg/g), superior photo‐thermal capacity (11.5°C enhancement in 180 s), low bio‐toxicity, good magnetic resonance with a low dosage of 22 μg/g, as well as high antitumor efficacy in vivo. Such a novel and multifunctional nanoplatform is expected to find promising applications in target tumor synergistic therapy.

中文翻译：

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具有近红外光响应的多功能双壳磁性纳米复合材料用于协同化学热肿瘤治疗

单一纳米平台的协同肿瘤治疗一直是高效肿瘤治疗的目标，但仍面临巨大挑战。本文报道了一种多功能纳米治疗平台，该平台包含磁性氧化铁纳米颗粒、聚多巴胺 (PDA)、金纳米笼 (Au nanocage) 和金属有机框架 (MOF、MIL101-NH ₂) 以实现在体外和体内的协同化学热肿瘤治疗。所制备的磁性光热纳米粒子（MPNPs）具有高载药量（31.34 mg/g）、优异的光热容量（180 s 内提高 11.5°C）、低生物毒性、良好的磁共振，低剂量为 22 μg /g，以及体内高抗肿瘤功效。这种新颖的多功能纳米平台有望在靶向肿瘤协同治疗中找到有希望的应用。