Orbital implants with interconnected porous architecture had gained prominence, as they were capable of being colonized by fibrovascular tissue and minimizing complications. However, mechanical properties of orbital implant had received little attention among existing design philosophy. Herein, a compliant porous silicone scaffold was developed by gelatin porogen‐leaching method and used as the orbital implant in this study. The silicone scaffolds exhibited desired microstructure and simulated mechanical properties, including high porosity of ~90%, suitable pore size of 280–450 μm, reduced modulus of 50.1 ± 11.7 KPa, and excellent elasticity. in vitro results showed that the porous silicone scaffolds did not exhibit noticeable cytotoxicity and were favorable for both adhesion and proliferation of human vascular ECs. The porous silicone scaffold was easy to be manipulated when implanted into the anophthalmic sockets of rabbits. The implanted scaffolds provided satisfactory volume replacement and induced extensive fibro‐vascularization, showing desirable orbital reconstruction effects. Therefore, our novel porous silicone scaffolds may be promising substitutes for current orbital implants.

中文翻译：

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弹性、大孔和快速血管化硅胶眼眶植入物的简易制造

具有相互连接的多孔结构的眼眶植入物已获得突出地位，因为它们能够被纤维血管组织定植并最大限度地减少并发症。然而，在现有的设计理念中，眼眶植入物的机械性能很少受到关注。在此，通过明胶致孔剂浸出法开发了一种柔顺的多孔硅胶支架，并在本研究中用作眼眶植入物。硅胶支架表现出所需的微观结构和模拟的机械性能，包括~90%的高孔隙率、280-450 μm的合适孔径、50.1±11.7 KPa的降低模量和出色的弹性。体外结果表明，多孔硅胶支架没有表现出明显的细胞毒性，并且有利于人血管内皮细胞的粘附和增殖。多孔硅胶支架在植入兔眼窝时易于操作。植入的支架提供了令人满意的容量替代并诱导了广泛的纤维血管形成，显示出理想的眼眶重建效果。因此，我们的新型多孔硅胶支架可能是当前眼眶植入物的有希望的替代品。