To date, a large number of mediators and biomarkers have been detected in childhood asthma, with a potential role in monitoring the disease course. In particular, the increased expression of prophlogistic markers, such as exhaled nitric oxide (eNO), sputum eosinophils, and serum Interleukin-8 (IL-8), showed clinical relevance having been correlated to lack of symptom control, despite the regular controller treatment1 . Lung function evaluation through spirometry, forced oscillation technique, and multiple breath washout, proved its role in asthma monitoring, especially for investigating small airway impairment in children with more severe symptoms2 . Nonetheless, the relationships between airway inflammation, lung function, and asthma severity in children need further investigation.

中文翻译：

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Resolvin D1 和 miR-146a 是中度和重度哮喘儿童的独立独特参数

迄今为止，已在儿童哮喘中检测到大量介质和生物标志物，在监测疾病过程中具有潜在作用。特别是，尽管进行了常规控制治疗，但炎性标志物（例如呼出气一氧化氮 (eNO)、痰嗜酸性粒细胞和血清白细胞介素 8 (IL-8)）的表达增加表明临床相关性与缺乏症状控制相关1 . 通过肺活量测定法、强制振荡技术和多次呼吸冲洗法评估肺功能，证明了其在哮喘监测中的作用，特别是用于调查症状更严重的儿童的小气道损伤2。尽管如此，儿童气道炎症、肺功能和哮喘严重程度之间的关系仍需进一步研究。